Role of Adiposity-Driven Inflammation in Depressive Morbidity.

Lucile Capuron, Julie Lasselin, Nathalie Castanon
Neuropsychopharmacol. 2016-07-11; 42(1): 115-128
DOI: 10.1038/npp.2016.123

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1. Neuropsychopharmacology. 2017 Jan;42(1):115-128. doi: 10.1038/npp.2016.123. Epub
2016 Jul 11.

Role of Adiposity-Driven Inflammation in Depressive Morbidity.

Capuron L(1)(2), Lasselin J(3)(4)(5), Castanon N(1)(2).

Author information:
(1)Laboratory of Nutrition and Integrative Neurobiology (NutriNeuro), INRA,
Bordeaux, France.
(2)University of Bordeaux, Nutrition and Integrative Neurobiology (NutriNeuro),
Bordeaux, France.
(3)Institute of Medical Psychology and Behavioral Immunobiology, Universitäts
Klinikum Essen, Essen, Germany.
(4)Department of Clinical Neuroscience, Division for Psychology, Karolinska
Institutet, Stockholm, Sweden.
(5)Stress Research Institute, Stockholm University, Stockholm, Sweden.

Depression and metabolic disorders, including overweight and obesity, appear
tightly interrelated. The prevalence of these conditions is concurrently growing
worldwide, and both depression and overweight/obesity represent substantial risk
factors for multiple medical complications. Moreover, there is now multiple
evidence for a bidirectional relationship between depression and increased
adiposity, with overweight/obesity being associated with an increased prevalence
of depression, and in turn, depression augmenting the risk of weight gain and
obesity. Although the reasons for this intricate link between depression and
increased adiposity remain unclear, converging clinical and preclinical evidence
points to a critical role for inflammatory processes and related alterations of
brain functions. In support of this notion, increased adiposity leads to a
chronic low-grade activation of inflammatory processes, which have been shown
elsewhere to have a potent role in the pathophysiology of depression. It is
therefore highly possible that adiposity-driven inflammation contributes to the
development of depressive disorders and their growing prevalence worldwide. This
review will present recent evidence in support of this hypothesis and will
discuss the underlying mechanisms and potential therapeutic targets. Altogether,
findings presented here should help to better understand the mechanisms linking
adiposity to depression and facilitate the identification of new preventive
and/or therapeutic strategies.

DOI: 10.1038/npp.2016.123
PMCID: PMC5143483
PMID: 27402495 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus