Risk of injurious road traffic crash after prescription of antidepressants

Ludivine Orriols, Raphaëlle Queinec, Pierre Philip, Blandine Gadegbeku, Bernard Delorme, Nicholas Moore, Samy Suissa, Emmanuel Lagarde,
J. Clin. Psychiatry. 2012-08-15; 73(08): 1088-1094
DOI: 10.4088/JCP.11m07624

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1. J Clin Psychiatry. 2012 Aug;73(8):1088-94.

Risk of injurious road traffic crash after prescription of antidepressants.

Orriols L(1), Queinec R, Philip P, Gadegbeku B, Delorme B, Moore N, Suissa S,
Lagarde E; CESIR Research Group.

Collaborators: Avalos M, Bazin F, Blazejewski S, Contrand B, Durrieu G, Girodet
PO, Goldberg M, Laumon B, Lauque D, Lecoules N, Memes L, Merle L, Montastruc JL,
Noize P, Orsoni N, Pariente A, Ribéreau-Gayon R, Salmi LR, Thiessard F, Tricotel

Author information:
(1)Université Bordeaux Segalen, Equipe Injury Prevention and Control (PPCT),
Institute of Public Health, Epidemiology, and Development (ISPED), Centre INSERM
U897-Epidemiologie-Biostatistique, F-33000, Bordeaux, France.

OBJECTIVE: To estimate the risk of road traffic crash associated with
prescription of antidepressants.
METHOD: Data were extracted and matched from 3 French national databases: the
national health care insurance database, police reports, and the national police
database of injurious crashes. A case-control analysis comparing 34,896
responsible versus 37,789 nonresponsible drivers was conducted. Case-crossover
analysis was performed to investigate the acute effect of medicine exposure.
RESULTS: 72,685 drivers, identified by their national health care number,
involved in an injurious crash in France from July 2005 to May 2008 were
included. 2,936 drivers (4.0%) were exposed to at least 1 antidepressant on the
day of the crash. The results showed a significant association between the risk
of being responsible for a crash and prescription of antidepressants (odds ratio
[OR] = 1.34; 95% CI, 1.22-1.47). The case-crossover analysis showed no
association with treatment prescription, but the risk of road traffic crash
increased after an initiation of antidepressant treatment (OR = 1.49; 95% CI,
1.24-1.79) and after a change in antidepressant treatment (OR = 1.32; 95% CI,
CONCLUSIONS: Patients and prescribers should be warned about the risk of crash
during periods of treatment with antidepressant medication and about particularly
high vulnerability periods such as those when a treatment is initiated or

© Copyright 2012 Physicians Postgraduate Press, Inc.

DOI: 10.4088/JCP.11m07624
PMID: 22967773 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus