Revisiting planar cell polarity in the inner ear
Seminars in Cell & Developmental Biology. 2013-05-01; 24(5): 499-506
DOI: 10.1016/j.semcdb.2013.03.012
Lire sur PubMed
1. Semin Cell Dev Biol. 2013 May;24(5):499-506. doi: 10.1016/j.semcdb.2013.03.012.
Epub 2013 Apr 3.
Revisiting planar cell polarity in the inner ear.
Ezan J(1), Montcouquiol M.
Author information:
(1)Planar Polarity and Plasticity Group, Inserm U862, Neurocentre Magendie,
Bordeaux, France.
Since the first implication of the core planar cell polarity (PCP) pathway in
stereocilia orientation of sensory hair cells in the mammalian cochlea, much has
been written about this subject, in terms of understanding how this pathway can
shape the mammalian hair cells and using the inner ear as a model system to
understand mammalian PCP signaling. However, many conflicting results have
arisen, leading to puzzling questions regarding the actual mechanism and roles of
core PCP signaling in mammals and invertebrates. In this review, we summarize our
current knowledge on the establishment of PCP during inner ear development and
revisit the contrast between wing epithelial cells in Drosophila melanogaster and
sensory epithelia in the mammalian cochlea. Notably, we focus on similarities and
differences in the asymmetric distribution of core PCP proteins in the context of
cell autonomous versus non-autonomous role of PCP signaling in the two systems.
Additionally, we address the relationship between the kinocilium position and PCP
in cochlear hair cells and increasing results suggest an alternate cell
autonomous pathway in regulating PCP in sensory hair cells.
Copyright © 2013 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.semcdb.2013.03.012
PMID: 23562830 [Indexed for MEDLINE]