Resting-State Brain Networks in Type 1 Diabetic Patients With and Without Microangiopathy and Their Relation to Cognitive Functions and Disease Variables
Diabetes. 2012-03-20; 61(7): 1814-1821
DOI: 10.2337/db11-1358
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1. Diabetes. 2012 Jul;61(7):1814-21. doi: 10.2337/db11-1358. Epub 2012 Mar 20.
Resting-state brain networks in type 1 diabetic patients with and without
microangiopathy and their relation to cognitive functions and disease variables.
van Duinkerken E(1), Schoonheim MM, Sanz-Arigita EJ, IJzerman RG, Moll AC, Snoek
FJ, Ryan CM, Klein M, Diamant M, Barkhof F.
Author information:
(1)Diabetes Center/Department of Internal Medicine, VU University Medical Center,
Amsterdam, the Netherlands.
Comment in
Diabetes. 2012 Jul;61(7):1653-5.
Cognitive functioning depends on intact brain networks that can be assessed with
functional magnetic resonance imaging (fMRI) techniques. We hypothesized that
cognitive decrements in type 1 diabetes mellitus (T1DM) are associated with
alterations in resting-state neural connectivity and that these changes vary
according to the degree of microangiopathy. T1DM patients with (MA(+): n = 49)
and without (MA(-): n = 52) microangiopathy were compared with 48 healthy control
subjects. All completed a neuropsychological assessment and resting-state fMRI.
Networks were identified using multisubject independent component analysis;
specific group differences within each network were analyzed using the
dual-regression method, corrected for confounding factors and multiple
comparisons. Relative to control subjects, MA(-) patients showed increased
connectivity in networks involved in motor and visual processes, whereas MA(+)
patients showed decreased connectivity in networks involving attention, working
memory, auditory and language processing, and motor and visual processes. Better
information-processing speed and general cognitive ability were related to
increased degree of connectivity. T1DM is associated with a functional
reorganization of neural networks that varies, dependent on the presence or
absence of microangiopathy.
DOI: 10.2337/db11-1358
PMCID: PMC3379683
PMID: 22438575 [Indexed for MEDLINE]