Resting Heart Rate Predicts Depression and Cognition Early after Ischemic Stroke: A Pilot Study.
Journal of Stroke and Cerebrovascular Diseases. 2017-10-01; 26(10): 2435-2441
DOI: 10.1016/j.jstrokecerebrovasdis.2017.05.040
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Tessier A(1), Sibon I(2), Poli M(3), Audiffren M(4), Allard M(5), Pfeuty M(6).
Author information:
(1)Département de psychiatrie adulte, Centre Hospitalier Charles Perrens,
CS81285, 33076 Bordeaux Cedex, France; Université de Bordeaux, INCIA, CNRS UMR
5287, F-33000 Bordeaux, France.
(2)Université de Bordeaux, INCIA, CNRS UMR 5287, F-33000 Bordeaux, France; CHU
Bordeaux, Neurologie, Unité Neurovasculaire, Bordeaux, France.
(3)CHU Bordeaux, Neurologie, Unité Neurovasculaire, Bordeaux, France.
(4)Université de Poitiers, CERCA, CNRS UMR 7295, F-86000 Poitiers, France.
(5)Université de Bordeaux, INCIA, CNRS UMR 5287, F-33000 Bordeaux, France; EPHE,
Bordeaux, France; CHU Bordeaux, Médecine Nucléaire, Bordeaux, France.
(6)Université de Bordeaux, INCIA, CNRS UMR 5287, F-33000 Bordeaux, France.
Electronic address: .
BACKGROUND: Early detection of poststroke depression (PSD) and cognitive
impairment (PSCI) remains challenging. It is well documented that the function
of autonomic nervous system is associated with depression and cognition.
However, their relationship has never been investigated in the early poststroke
phase. This pilot study aimed at determining whether resting heart rate (HR)
parameters measured in early poststroke phase (1) are associated with
early-phase measures of depression and cognition and (2) could be used as new
tools for early objective prediction of PSD or PSCI, which could be applicable
to patients unable to answer usual questionnaires.
METHODS: Fifty-four patients with first-ever ischemic stroke, without cardiac
arrhythmia, were assessed for resting HR and heart rate variability (HRV) within
the first week after stroke and for depression and cognition during the first
week and at 3 months after stroke.
RESULTS: Multiple regression analyses controlled for age, gender, and stroke
severity revealed that higher HR, lower HRV, and higher sympathovagal balance
(low-frequency/high-frequency ratio of HRV) were associated with higher severity
of depressive symptoms within the first week after stroke. Furthermore, higher
sympathovagal balance in early phase predicted higher severity of depressive
symptoms at the 3-month follow-up, whereas higher HR and lower HRV in early
phase predicted lower global cognitive functioning at the 3-month follow-up.
CONCLUSIONS: Resting HR measurements obtained in early poststroke phase could
serve as an objective tool, applicable to patients unable to complete
questionnaires, to help in the early prediction of PSD and PSCI.
Copyright © 2017 National Stroke Association. Published by Elsevier Inc. All
rights reserved.
DOI: 10.1016/j.jstrokecerebrovasdis.2017.05.040
PMID: 28652061 [Indexed for MEDLINE]