Reply to: Deep brain stimulation in Parkinson’s disease can mimic the 300 Hz subthalamic rhythm Subthalamic high-frequency stimulation drives subthalamic oscillatory activity at stimulation frequency while firing rate is reduced [5]

W. Meissner, A. Leblois, A. Benazzouz, T. Boraud
Brain. 2006-06-09; 129(12): e60-e60
DOI: 10.1093/brain/awl210

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1. Cell Rep. 2018 Aug 7;24(6):1667-1678. doi: 10.1016/j.celrep.2018.07.018.

Olfactory Neurons and Brain Centers Directing Oviposition Decisions in
Drosophila.

Chin SG(1), Maguire SE(1), Huoviala P(2), Jefferis GSXE(2), Potter CJ(3).

Author information:
(1)Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School
of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA.
(2)Division of Neurobiology, MRC Laboratory of Molecular Biology, Francis Crick
Avenue, Cambridge CB2 OQH, UK.
(3)Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School
of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA. Electronic address:
*protected email*.

The sense of smell influences many behaviors, yet how odors are represented in
the brain remains unclear. A major challenge to studying olfaction is the lack of
methods allowing activation of specific types of olfactory neurons in an
ethologically relevant setting. To address this, we developed a genetic method in
Drosophila called olfactogenetics in which a narrowly tuned odorant receptor,
Or56a, is ectopically expressed in different olfactory neuron types. Stimulation
with geosmin (the only known Or56a ligand) in an Or56a mutant background leads to
specific activation of only target olfactory neuron types. We used this approach
to identify olfactory sensory neurons (OSNs) that directly guide oviposition
decisions. We identify 5 OSN-types (Or71a, Or47b, Or49a, Or67b, and Or7a) that,
when activated alone, suppress oviposition. Projection neurons partnering with
these OSNs share a region of innervation in the lateral horn, suggesting that
oviposition site selection might be encoded in this brain region.

Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

DOI: 10.1016/j.celrep.2018.07.018
PMID: 30089274


Auteurs Bordeaux Neurocampus