Remodeling of the neuronal circuits underlying opiate-withdrawal memories following remote retrieval
Neurobiology of Learning and Memory. 2012-01-01; 97(1): 47-53
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1. Neurobiol Learn Mem. 2012 Jan;97(1):47-53. doi: 10.1016/j.nlm.2011.09.002. Epub
2011 Sep 16.
Remodeling of the neuronal circuits underlying opiate-withdrawal memories
following remote retrieval.
Lucas M(1), Frenois F, Cador M, Le Moine C.
(1)Université de Bordeaux, CNRS UMR 5287, INCIA, Bordeaux, France.
Several types of memory display time-dependent reorganization of their underlying
neural substrates, but it remains unclear whether affective memories associated
with drug effects also follow similar reorganization. Here, we analyzed the
neural circuits reactivated by the re-exposure of former dependent rats to the
withdrawal-paired environment 1month after conditioning (remote memory) as
compared with recent memory (Frenois, F., Stinus, L., Di Blasi, F., Cador, M., &
Le Moine, C. (2005) A specific limbic circuit underlies opiate withdrawal
memories The Journal of Neuroscience, 25, 1366-1374). C-fos expression showed
that the circuits involved in the retrieval of withdrawal memories are partly
different when comparing recent and remote reactivation, showing that, like other
type of memories, affective memories linked to opiate withdrawal undergo
anatomical reorganization, with a shift from extended amygdala regions toward
Copyright © 2011 Elsevier Inc. All rights reserved.
PMID: 21945836 [Indexed for MEDLINE]