Relationships between individual sensitivity to CS- and cocaine-induced reinstatement in the rat.

V. Deroche-Gamonet, A. Martinez, M. Le Moal, P. V. Piazza
Psychopharmacology. 2003-02-13; 168(1-2): 201-207
DOI: 10.1007/s00213-002-1306-9

PubMed
Lire sur PubMed



1. Psychopharmacology (Berl). 2003 Jul;168(1-2):201-207. doi:
10.1007/s00213-002-1306-9. Epub 2003 Feb 13.

Relationships between individual sensitivity to CS- and cocaine-induced
reinstatement in the rat.

Deroche-Gamonet V(1), Martinez A(1), Le Moal M(1), Piazza PV(2).

Author information:
(1)Laboratoire de Psychobiologie des Comportements Adaptatifs, Domaine de
Carreire, Rue Camille Saint-Saëns, 33077 Bordeaux, France, France.
(2)Laboratoire de Psychobiologie des Comportements Adaptatifs, Domaine de
Carreire, Rue Camille Saint-Saëns, 33077 Bordeaux, France, France.
.

RATIONALE: Maintaining abstinence is highly challenging for cocaine ex-users.
Exposure to drug conditioned stimuli (CS) and to low doses of cocaine can provoke
craving in humans and reinstate self-administration (SA) behavior in animal
models. Whether drug- and CS-induced reinstatement depend on the same biological
substrates remains controversial.
OBJECTIVES: We investigated the relationships between cocaine- and CS-induced SA
reinstatement within the same individuals as a function of the duration of the
withdrawal period after cessation of extended cocaine SA.
METHODS: Sprague-Dawley rats were trained for cocaine intravenous SA (0.8 mg/kg
per infusion) during 74 sessions (2 h daily exposure to cocaine) and submitted to
withdrawal. Five and 30 days after the end of SA, cocaine- and CS-induced
reinstatement were tested.
RESULTS: Both after a short and a long withdrawal, CS- and cocaine-induced
reinstatement were not related. Furthermore, cocaine-induced reinstatement
measured after a short and a long withdrawal was positively related while
CS-induced reinstatement was not. The sensitivity of an individual to
cocaine-induced reinstatement is not related to its sensitivity to CS-induced
reinstatement. Furthermore, vulnerability to cocaine-induced reinstatement is
determined quickly after SA cessation and is a long lasting state, whilst
vulnerability to CS-induced reinstatement develops quickly or slowly depending on
the individual.
CONCLUSIONS: These results support the view that cocaine and CS induce
reinstatement through different mechanisms. They imply that reinstatement in drug
abuse is a heterogeneous condition with some individuals being more sensitive to
one factor than to the other. Research for effective anti-relapse therapies
should take these elements into account.

DOI: 10.1007/s00213-002-1306-9
PMID: 12589518 [Indexed for MEDLINE]


Auteurs Bordeaux Neurocampus