Regional cerebral blood flow increases during wakeful rest following cognitive training
Brain Research Bulletin. 2009-09-01; 80(3): 133-138
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1. Brain Res Bull. 2009 Sep 28;80(3):133-8. doi: 10.1016/j.brainresbull.2009.06.021.
Epub 2009 Jul 7.
Regional cerebral blood flow increases during wakeful rest following cognitive
Mazoyer B(1), Houdé O, Joliot M, Mellet E, Tzourio-Mazoyer N.
(1)Centre d’Imagerie-Neurosciences et Applications aux Pathologies, CI-NAPS
UMR6232, CNRS, CEA I2BM, GIP Cyceron, France.
Positron tomography was used to investigate modulations of brain activity during
the so-called resting state that may occur due to a concurrent cognitive
training. Twelve subjects were repeatedly scanned during resting periods and
while solving logical problems containing a bias causing them to make reasoning
errors. At experiment mid-time, eight subjects were trained to inhibit the
reasoning bias so that their performance in solving logical problems dramatically
increased afterwards, while the other four subjects were trained to logical
reasoning only which did not help improving their performance. In the subgroup of
subjects who increased their performance after training, we found that during the
post-training resting periods, as compared to pre-training resting periods, brain
activity increases in areas not belonging to the classical resting network,
namely the midbrain, thalamus, peristriate, inferior frontal, and ventromedial
prefrontal cortices. Strikingly, in this subgroup of subjects, these same areas
were found to be also more active during post-training successful execution of
the logical task, as compared to pre-training erroneous execution of the task.
Such findings were not observed in the subgroup of subjects who did not improve
their performance after training to logic only. These results indicate that the
brain default mode is a dynamic state during which context dependent local
increases of cerebral blood flow may occur on a short-term, likely for the
consolidation of newly acquired knowledge.
PMID: 19589374 [Indexed for MEDLINE]