Regional brain atrophy development is related to specific aspects of clinical dysfunction in multiple sclerosis

Bas Jasperse, Hugo Vrenken, Ernesto Sanz-Arigita, Vincent de Groot, Stephen M. Smith, Chris H. Polman, Frederik Barkhof
NeuroImage. 2007-11-01; 38(3): 529-537
DOI: 10.1016/j.neuroimage.2007.07.056

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1. Neuroimage. 2007 Nov 15;38(3):529-37. Epub 2007 Aug 16.

Regional brain atrophy development is related to specific aspects of clinical
dysfunction in multiple sclerosis.

Jasperse B(1), Vrenken H, Sanz-Arigita E, de Groot V, Smith SM, Polman CH,
Barkhof F.

Author information:
(1)Department of Neurology, VU University Medical Center, Boelelaan 1117, PO Box
7057, 1007 MB, Amsterdam, The Netherlands.

Brain atrophy in multiple sclerosis (MS) is thought to reflect irreversible
tissue damage leading to persistent clinical deficit. Little is known about the
rate of atrophy in specific brain regions in relation to specific clinical
deficits. We determined the displacement of the brain surface between two
T1-weighted MRI images obtained at baseline and after a median follow-up time of
2.2 years for 79 recently diagnosed, mildly disabled MS patients. Voxel- and
cluster-wise permutation-based statistics were used to identify brain regions in
which atrophy development was significantly related to Expanded Disability Status
Scale (EDSS), Timed Walk Test (TWT), Paced Auditory Serial Addition Test (PASAT)
and 9-Hole Peg Test (HPT). Clusters were considered significant at a corrected
cluster-wise p-value of 0.05. Worse EDSS change-score and worse follow-up EDSS
were related to atrophy development of periventricular and brainstem regions and
right-sided parietal, occipital and temporal regions. Worse PASAT at follow-up
was significantly related to atrophy of the ventricles. A worse TWT change-score
and worse follow-up TWT were exclusively related to atrophy around the ventricles
and of the brainstem. Worse HPT change-score and worse follow-up HPT of either
arm were significantly related to the atrophy of widely distributed peripheral
regions, as well as atrophy of periventricular and brainstem regions. Our
findings suggest that decline in ambulatory function is related to atrophy of
central brain regions exclusively, whereas decline in neurologically more complex
tasks for coordinated hand function is related to atrophy of both central and
peripheral brain regions.

DOI: 10.1016/j.neuroimage.2007.07.056
PMID: 17889567 [Indexed for MEDLINE]

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