Reconsolidation after remembering an odor-reward association requires NMDA receptors

M. Torras-Garcia
Learning & Memory. 2005-01-01; 12(1): 18-22
DOI: 10.1101/lm.80905

PubMed
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A rapidly learned odor discrimination task based on spontaneous foraging behavior
of the rat was used to evaluate the role of N-methyl-D-aspartate (NMDA) receptors
(NMDARs) in ongoing memory consolidation. Rats were trained in a single session
to discriminate among three odors, one of which was associated with palatable
food reward. Previous experiments showed that the NMDAR antagonist DL-APV induced
amnesia for this task when injected immediately after training. In the present
study, memory was reactivated 24 h after training by exposure to the rewarded
odor within the experimental context after which rats received an
intracerebroventricular injection of APV. Combined reactivation-drug treatment
induced profound amnesia when tested 48 h later. Animals receiving drug alone, in
absence of reactivation, showed perfect retention. It is concluded that NMDARs
support a consolidation process taking place after memory reactivation.

Auteurs Bordeaux Neurocampus