Reconfiguration of the neural network controlling multiple breathing patterns: eupnea, sighs and gasps
Nat Neurosci. 2000-06-01; 3(6): 600-607
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Lieske SP(1), Thoby-Brisson M, Telgkamp P, Ramirez JM.
(1)Committee on Neurobiology, The University of Chicago, 1027 East 57th Street
Chicago, Illinois 60637, USA.
Nat Neurosci. 2000 Jun;3(6):531-2.
Are different forms of breathing derived from one or multiple neural networks? We
demonstrate that brainstem slices containing the pre-Bötzinger complex generated
two rhythms when normally oxygenated, with striking similarities to eupneic
(‘normal’) respiration and sighs. Sighs were triggered by eupneic bursts under
control conditions, but not in the presence of strychnine (1 microM). Although
all neurons received synaptic inputs during both activities, the calcium channel
blocker cadmium (4 microM) selectively abolished sighs. In anoxia, sighs ceased,
and eupneic activity was reconfigured into gasping, which like eupnea was
insensitive to 4 microM cadmium. This reconfiguration was accompanied by
suppression of synaptic inhibition. We conclude that a single medullary network
underlies multiple breathing patterns.
PMID: 10816317 [Indexed for MEDLINE]