Recommendations of the Schizophrenia Expert Center network for adequate physical activity in real-world schizophrenia (FACE-SZ).

Pierre-Louis Sunhary De Verville, Brendon Stubbs, Damien Etchecopar-Etchart, Ophélia Godin, Christelle Andrieu-Haller, Fabrice Berna, Bruno Aouizerate, Delphine Capdevielle, Isabelle Chereau, Julie Clauss-Kobayashi, Nathalie Coulon, Jean-Michel Dorey, Caroline Dubertret, Sylvain Leignier, Jasmina Mallet, David Misdrahi, Catherine Passerieux, Baptiste Pignon, Romain Rey, Mathieu Urbach, Pierre-Michel Llorca, Franck Schürhoff, Christophe Lançon, Laurent Boyer, Guillaume Fond, , M. Andre, C. Andrieu-Haller, B. Aouizerate, F. Berna, O. Blanc, E. Bourguignon, D. Capdevielle, I. Chereau-Boudet, J. Clauss-Kobayashi, N. Coulon, R. Dassing, J. M. Dorey, C. Dubertret, A. Esselin, G. Fond, F. Gabayet, M. Jarroir, D. Lacelle, M. Leboyer, S. Leignier, P. M. Llorca, J. Mallet, E. Metairie, T. Michel, D. Misdrahi, C. Passerieux, J. Petrucci, B. Pignon, P. Peri, C. Portalier, R. Rey, C. Roman, B. Schorr, F. Schürhoff, A. Szöke, A. Tessier, M. Urbach, G. Wachiche, A. Zinetti-Bertschy
Eur Arch Psychiatry Clin Neurosci. 2022-04-20; 272(7): 1273-1282
DOI: 10.1007/s00406-022-01384-x

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1. Eur Arch Psychiatry Clin Neurosci. 2022 Oct;272(7):1273-1282. doi:
10.1007/s00406-022-01384-x. Epub 2022 Apr 20.

Recommendations of the Schizophrenia Expert Center network for adequate physical
activity in real-world schizophrenia (FACE-SZ).

Sunhary De Verville PL(1)(2), Stubbs B(3)(4), Etchecopar-Etchart D(1)(2), Godin
O(1)(5), Andrieu-Haller C(1)(2), Berna F(1)(6), Aouizerate B(1)(7)(8),
Capdevielle D(1)(9), Chereau I(1)(10), Clauss-Kobayashi J(1)(6), Coulon
N(1)(11), Dorey JM(1)(12), Dubertret C(1)(13), Leignier S(1)(11), Mallet
J(1)(13), Misdrahi D(1)(7)(14), Passerieux C(1)(15)(16), Pignon B(1)(5), Rey
R(1)(12), Urbach M(1)(15)(16), Llorca PM(1)(10), Schürhoff F(1)(5), Lançon
C(1)(2), Boyer L(1)(2), Fond G(17)(18); Collaborators: the FACE-S. Z.
(FondaMental Academic Centers of Expertise for Schizophrenia) Group.

Collaborators: Andre M, Andrieu-Haller C, Aouizerate B, Berna F, Blanc O,
Bourguignon E, Capdevielle D, Chereau-Boudet I, Clauss-Kobayashi J, Coulon N,
Dassing R, Dorey JM, Dubertret C, Esselin A, Fond G, Gabayet F, Jarroir M,
Lacelle D, Leboyer M, Leignier S, Llorca PM, Mallet J, Metairie E, Michel T,
Misdrahi D, Passerieux C, Petrucci J, Pignon B, Peri P, Portalier C, Rey R,
Roman C, Schorr B, Schürhoff F, Szöke A, Tessier A, Urbach M, Wachiche G,
Zinetti-Bertschy A.

Author information:
(1)Fondation FondaMental, Créteil, France.
(2)AP-HM, Aix-Marseille Univ, Faculté de Médecine-Secteur Timone, EA 3279:
CEReSS-Centre d’Etude et de Recherche sur les Services de Santé et la Qualité de
vie, 27 Boulevard Jean Moulin, 13005, Marseille, France.
(3)South London and Maudsley NHS Foundation Trust, Denmark Hill, London, SE5
8AZ, UK.
(4)Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College
London, London, UK.
(5)Université Paris Est Creteil (UPEC), AP-HP, Hôpitaux Universitaires « H.
Mondor », DMU IMPACT, INSERM, IMRB, Translational Neuropsychiatry, Fondation
FondaMental, 94010, Creteil, France.
(6)Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, INSERM
U1114, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg,
France.
(7)Pôle de Psychiatrie Générale Et Universitaire, Centre Hospitalier Charles
Perrens, 33076 Université de Bordeaux, CNRS UMR 5287-INCIA, Bordeaux, France.
(8)INRA, NutriNeuro, University of Bordeaux, U1286, 33076, Bordeaux, France.
(9)Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU
Montpellier, IGF, Univ. Montpellier, CNRS, INSERM, Montpellier, France.
(10)Université Clermont Auvergne, CMP-B, CHU, CNRS, Clermont Auvergne INP,
Institut Pascal, 63000, Clermont-Ferrand, France.
(11)Centre Référent de Réhabilitation Psychosociale, CH Alpes Isère, Grenoble,
France.
(12)INSERM U1028, CNRS UMR5292, Centre de Recherche en Neurosciences de Lyon,
Université Claude Bernard Lyon 1, Equipe PSYR2, Centre Hospitalier Le Vinatier,
Pole Est, 95 bd Pinel, BP 30039, 69678, Bron Cedex, France.
(13)Department of Psychiatry, Université de Paris, AP-HP, Louis Mourier
Hospital, Colombes, INSERM UMR 1266, Colombes, France.
(14)CNRS UMR 5287-INCIA, Paris, France.
(15)Service Universitaire de Psychiatrie d’Adultes et d’Addictologie, Centre
Hospitalier de Versailles, 177 rue de Versailles, 78157, Le Chesnay, France.
(16)DisAP-DevPsy-CESP, INSERM UMR1018, Université Paris-Saclay, Université
Versailles Saint-Quentin-En-Yvelines, 94807, Villejuif,, France.
(17)Fondation FondaMental, Créteil, France. .
(18)AP-HM, Aix-Marseille Univ, Faculté de Médecine-Secteur Timone, EA 3279:
CEReSS-Centre d’Etude et de Recherche sur les Services de Santé et la Qualité de
vie, 27 Boulevard Jean Moulin, 13005, Marseille, France.
.

The World Health Organization (WHO) recommends adults complete 150-300 min per
week of moderate physical activity or 75-150 min of vigorous physical activity
or an equivalent combination of both, to optimize health. To explore the factors
associated with adequate MVPA in stabilized outpatients with schizophrenia. 425
stabilized outpatients were recruited in the national FACE-SZ cohort between
2015 and 2018 were evaluated with the International Physical Activity
Questionnaire and a 1-day long standardized battery. We explored in multivariate
analyses the clinical and pharmacological factors associated with MVPA (model 1)
and the biological factors and patient-reported outcomes (model 2). Overall,
only 86 (20.2%) of the 425 participants achieved the recommended MVPA threshold.
In model 1, the adequate MVPA group was associated with younger age, mood
stabilizers prescription and adherence to treatment, independent of sex,
positive and depressive symptoms, first-generation antipsychotics prescription,
anxiolytic medication, and akathisia. In model 2, adequate MVPA was associated
with better glycemic and lipidic profile and better physical and psychological
well-being, self-esteem, sentimental life, and resilience independently of age,
sex, and current psychotic severity. The expert centers recommend the importance
of promoting promote effective MVPA programs for stabilized patients with
schizophrenia. Interventions studies suggest that MVPA may be a useful strategy
to maximize physical and psychological well-being and self-esteem and
potentially to prevent or manage metabolic disturbances.