Reasoning by analogy requires the left frontal pole: lesion-deficit mapping and clinical implications.
Brain. 2016-04-13; 139(6): 1783-1799
DOI: 10.1093/brain/aww072
Lire sur PubMed
1. Brain. 2016 Jun;139(Pt 6):1783-99. doi: 10.1093/brain/aww072. Epub 2016 Apr 13.
Reasoning by analogy requires the left frontal pole: lesion-deficit mapping and
clinical implications.
Urbanski M(1), Bréchemier ML(2), Garcin B(2), Bendetowicz D(2), Thiebaut de
Schotten M(3), Foulon C(3), Rosso C(4), Clarençon F(5), Dupont S(6), Pradat-Diehl
P(7), Labeyrie MA(8), Levy R(9), Volle E(10).
Author information:
(1)1 Inserm, U 1127, 75013 Paris, France 2 CNRS, UMR 7225, 75013 Paris, France 3
Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, 75013 Paris, France 4 ICM,
FrontLab, 75013 Paris, France 5 Hôpitaux de Saint-Maurice, Medicine and
Rehabilitation Department, 94410 Saint-Maurice, France.
(2)1 Inserm, U 1127, 75013 Paris, France 2 CNRS, UMR 7225, 75013 Paris, France 3
Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, 75013 Paris, France 4 ICM,
FrontLab, 75013 Paris, France.
(3)1 Inserm, U 1127, 75013 Paris, France 2 CNRS, UMR 7225, 75013 Paris, France 3
Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, 75013 Paris, France 4 ICM,
FrontLab, 75013 Paris, France 6 ICM, Brain Connectivity and Behaviour, 75013
Paris, France.
(4)1 Inserm, U 1127, 75013 Paris, France 2 CNRS, UMR 7225, 75013 Paris, France 3
Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, 75013 Paris, France 7
AP-HP, Hôpital de la Salpêtrière, Stroke Centre, 75013 Paris, France.
(5)8 AP-HP, Hôpital de la Salpêtrière, Neuroradiology Department, 75013 Paris,
France.
(6)9 AP-HP, Hôpital de la Salpêtrière, Epileptology Department, 75013 Paris,
France.
(7)10 AP-HP, Hôpital de la Salpêtrière, Physical Medicine and Rehabilitation
Department, 75013 Paris, France.
(8)11 AP-HP, Hôpital Lariboisière, Neuroradiology Department, 75010 Paris,
France.
(9)1 Inserm, U 1127, 75013 Paris, France 2 CNRS, UMR 7225, 75013 Paris, France 3
Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, 75013 Paris, France 12
AP-HP, Hôpital de la Salpêtrière, Behavioural Neuropsychiatry Unit, 75013 Paris,
France.
(10)1 Inserm, U 1127, 75013 Paris, France 2 CNRS, UMR 7225, 75013 Paris, France 3
Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, 75013 Paris, France 4 ICM,
FrontLab, 75013 Paris, France 6 ICM, Brain Connectivity and Behaviour, 75013
Paris, France 13 CENIR, ICM, 75013 Paris, France .
Comment in
Brain. 2016 Jun;139(Pt 6):1627-30.
SEE BURGESS DOI101093/BRAIN/AWW092 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE :
Analogical reasoning is at the core of the generalization and abstraction
processes that enable concept formation and creativity. The impact of
neurological diseases on analogical reasoning is poorly known, despite its
importance in everyday life and in society. Neuroimaging studies of healthy
subjects and the few studies that have been performed on patients have
highlighted the importance of the prefrontal cortex in analogical reasoning.
However, the critical cerebral bases for analogical reasoning deficits remain
elusive. In the current study, we examined analogical reasoning abilities in 27
patients with focal damage in the frontal lobes and performed voxel-based
lesion-behaviour mapping and tractography analyses to investigate the structures
critical for analogical reasoning. The findings revealed that damage to the left
rostrolateral prefrontal region (or some of its long-range connections)
specifically impaired the ability to reason by analogies. A short version of the
analogy task predicted the existence of a left rostrolateral prefrontal lesion
with good accuracy. Experimental manipulations of the analogy tasks suggested
that this region plays a role in relational matching or integration. The current
lesion approach demonstrated that the left rostrolateral prefrontal region is a
critical node in the analogy network. Our results also suggested that analogy
tasks should be translated to clinical practice to refine the neuropsychological
assessment of patients with frontal lobe lesions.
© The Author (2016). Published by Oxford University Press on behalf of the
Guarantors of Brain. All rights reserved. For Permissions, please email:
.
DOI: 10.1093/brain/aww072
PMID: 27076181 [Indexed for MEDLINE]