Quality of life is associated with chronic inflammation in schizophrenia: A cross-sectional study
Sci Rep. 2015-06-04; 5(1):
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1. Sci Rep. 2015 Jun 4;5:10793. doi: 10.1038/srep10793.
Quality of life is associated with chronic inflammation in schizophrenia: a
Faugere M(1), Micoulaud-Franchi JA(2), Alessandrini M(3), Richieri R(1),
Faget-Agius C(1), Auquier P(3), Lançon C(1), Boyer L(3).
(1)1] Department of Psychiatry, La Conception University Hospital, 13009
Marseille, France  Aix-Marseille Univ., EA 3279 – Public Health, Chronic
Diseases and Quality of Life – Research Unit, 13005 Marseille, France.
(2)1] Department of Clinical Neurophysiology, Sleep Clinique, Pellegrin
University Hospital, 33076 Bordeaux, France  Bordeaux University, USR CNRS
3413 SANPSY, Research Unit, 33000 Bordeaux, France.
(3)Aix-Marseille Univ., EA 3279 – Public Health, Chronic Diseases and Quality of
Life – Research Unit, 13005 Marseille, France.
Inflammation may play a crucial role in the pathogenesis of schizophrenia.
However, the association between chronic inflammation and health outcomes in
schizophrenia remains unclear, particularly for patient-reported outcomes. The
aim of this study was to investigate the relationship between quality of life
(QoL) and chronic inflammation assessed using C -Reactive Protein (CRP) in
patients with schizophrenia. Two hundred and fifty six patients with
schizophrenia were enrolled in this study. After adjusting for key
socio-demographic and clinical confounding factors, patients with high levels of
CRP (>3.0 mg/l) had a lower QoL than patients with normal CRP levels (OR = 0.97,
95% CI = 0.94-0.99). An investigation of the dimensions of QoL revealed that
psychological well-being, physical well-being and sentimental life were the most
salient features of QoL associated with CRP. Significant associations were found
between lower educational level (OR = 4.15, 95% CI = 1.55-11.07), higher body
mass index (OR = 1.16, 95% CI = 1.06-1.28), higher Fagerström score (OR = 1.22,
95% CI = 1.01-1.47) and high levels of CRP. After replications with longitudinal
approaches, the association between QoL and chronic inflammation may offer
interesting interventional prospects to act both on inflammation and QoL in
patients with schizophrenia.
PMID: 26041435 [Indexed for MEDLINE]