Quality of life is associated with chronic inflammation in depression: A cross-sectional study.
Journal of Affective Disorders. 2018-02-01; 227: 494-497
DOI: 10.1016/j.jad.2017.11.061
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1. J Affect Disord. 2018 Feb;227:494-497. doi: 10.1016/j.jad.2017.11.061. Epub 2017
Nov 14.
Quality of life is associated with chronic inflammation in depression: A
cross-sectional study.
Faugere M(1), Micoulaud-Franchi JA(2), Faget-Agius C(3), Lançon C(3), Cermolacce
M(4), Richieri R(5).
Author information:
(1)Department of Psychiatry, La Conception University Hospital, 13005 Marseille,
France; EA 3279 – Self perceived Health Assessment Research Unit, Aix-Marseille
University, 13005 Marseille, France. Electronic address:
.
(2)Department of Clinical Neurophysiology, Sleep Clinique, Pellegrin University
Hospital, 33076 Bordeaux, France; Bordeaux University, USR CNRS 3413 SANPSY,
Research Unit, 33000 Bordeaux, France.
(3)Department of Psychiatry, La Conception University Hospital, 13005 Marseille,
France; EA 3279 – Self perceived Health Assessment Research Unit, Aix-Marseille
University, 13005 Marseille, France.
(4)SHU Adult Psychiatry, Sainte Marguerite University Hospital, 13274 Marseille,
France.
(5)Department of Psychiatry, La Conception University Hospital, 13005 Marseille,
France; EA 3279 – Self perceived Health Assessment Research Unit, Aix-Marseille
University, 13005 Marseille, France; Department of Psychosis studies, Institute
of Psychiatry, Psychology and Neurosciences, King’s College London, United
Kingdom.
BACKGROUND: Inflammation may play a crucial role in the pathophysiology of
depression. However, the association between chronic inflammation and health
outcomes in depression remains unclear, particularly for patient-reported
outcomes.
METHODS: The aim of this study was to investigate the relationship between
quality of life (QoL) (physical and mental health, assessed by the SF-36) and
chronic inflammation assessed using C-reactive protein (CRP) in patients with
current major depressive disorder.
RESULTS: One hundred eighty-one patients with depression were enrolled in this
study. After adjusting for key socio-demographic, clinical and biological
confounding factors, patients with high levels of CRP (> 3.0mg/L) had worse
physical health than those with normal CRP levels (OR = 0.95, 95% CI =
0.92-0.99). Significant associations were found between a higher rate of
metabolic syndrome (OR = 0.10, 95% CI = 0.02-0.41) and high CRP levels.
LIMITATIONS: The cut-off point for high cardiovascular risk was used to define
the two groups: normal CRP level and high CRP level. CRP was the sole marker of
inflammation in this study and was collected at only one time point. The design
of this study is cross-sectional and there are no conclusions about the
directionality of the association between QoL and inflammation in depression. QoL
was assessed only by SF-36 scores.
CONCLUSION: This study found an association between SF-36 physical health score
and CRP in patients with depression, thereby showing the need to consider
physical well-being in depression. This paves the way for interventions to act
both on inflammation and QoL in patients with depression.
Copyright © 2017 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.jad.2017.11.061
PMID: 29156363