QTLs influencing carbohydrate and fat choice in a LOU/CxFischer 344 F2 rat population.
Obesity. 2013-07-05; 22(2): 565-575
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1. Obesity (Silver Spring). 2014 Feb;22(2):565-75. doi: 10.1002/oby.20485. Epub 2013
QTLs influencing carbohydrate and fat choice in a LOU/CxFischer 344 F2 rat
Marissal-Arvy N(1), Diane A, Moisan MP, Larue-Achagiotis C, Tridon C, Tome D,
Fromentin G, Mormède P.
(1)INRA, Laboratory of Nutrition and Integrative Neurobiology, UMR 1286, 33076
Bordeaux Cedex, France; Laboratory of Nutrition and Integrative Neurobiology,
University of Bordeaux, UMR 1286, 33076 Bordeaux Cedex, France.
OBJECTIVE: Individual differences in macronutrient selection, particularly fat
and carbohydrate, and associated body weight gain are partly inherited as
polygenic traits, but the potential genetic pathways are unknown. To give an
overview of the Quantitative Trait Loci (QTLs) and candidate gene pathways
influencing these differences in rat was aimed in this study.
DESIGN AND METHODS: To that end, F2 rats obtained from the crossbreeding between
LOU/C and Fischer 344 rat strains to diet self-selection during 3 weeks were
submitted. A genome scan was conducted with microsatellite markers covering
evenly the whole genome. Genotypes and phenotypes were analyzed separately in
male and female F2 rats by multiple interval mapping. Then, lists of candidate
genes were treated by the Ingenuity Pathway software to propose gene pathways
involved in our phenotypes.
RESULTS: Among numerous others, a QTL on chromosome 12 that influences body
weight gain, and fat and carbohydrate choices in the LOU/C x Fischer 344 F2 rat
population was found. This locus contains notably the acyl-co-A dehydrogenase
CONCLUSION: A strong genetic determinism and complex pathways involving numerous
candidate genes and processes, notably in accordance with the metabolic theory of
feeding behavior control were found.
Copyright © 2013 The Obesity Society.
PMID: 23596094 [Indexed for MEDLINE]