Pyramidal cell-interneuron interactions underlie hippocampal ripple oscillations.
Neuron. 2014-07-01; 83(2): 467-480
DOI: 10.1016/j.neuron.2014.06.023
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1. Neuron. 2014 Jul 16;83(2):467-480. doi: 10.1016/j.neuron.2014.06.023.
Pyramidal cell-interneuron interactions underlie hippocampal ripple oscillations.
Stark E(1), Roux L(2), Eichler R(2), Senzai Y(2), Royer S(3), Buzsáki G(4).
Author information:
(1)NYU Neuroscience Institute, School of Medicine, New York University, New York,
NY 10016, USA. Electronic address: .
(2)NYU Neuroscience Institute, School of Medicine, New York University, New York,
NY 10016, USA.
(3)Korea Institute of Science and Technology, Seoul, South Korea.
(4)NYU Neuroscience Institute, School of Medicine, New York University, New York,
NY 10016, USA. Electronic address: .
High-frequency ripple oscillations, observed most prominently in the hippocampal
CA1 pyramidal layer, are associated with memory consolidation. The cellular and
network mechanisms underlying the generation, frequency control, and spatial
coherence of the rhythm are poorly understood. Using multisite optogenetic
manipulations in freely behaving rodents, we found that depolarization of a small
group of nearby pyramidal cells was sufficient to induce high-frequency
oscillations, whereas closed-loop silencing of pyramidal cells or activation of
parvalbumin- (PV) or somatostatin-immunoreactive interneurons aborted
spontaneously occurring ripples. Focal pharmacological blockade of GABAA
receptors abolished ripples. Localized PV interneuron activation paced ensemble
spiking, and simultaneous induction of high-frequency oscillations at multiple
locations resulted in a temporally coherent pattern mediated by phase-locked
interneuron spiking. These results constrain competing models of ripple
generation and indicate that temporally precise local interactions between
excitatory and inhibitory neurons support ripple generation in the intact
hippocampus.
Copyright © 2014 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.neuron.2014.06.023
PMCID: PMC4393648
PMID: 25033186 [Indexed for MEDLINE]