Psychotropic Drugs and the Microbiome
Modern Trends in Psychiatry. 2021-01-01; : 113-133
DOI: 10.1159/000510423
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1. Mod Trends Psychiatry. 2021;32:113-133. doi: 10.1159/000510423. Epub 2021 May
6.
Psychotropic Drugs and the Microbiome.
Cussotto S(1), Clarke G(2), Dinan TG(2), Cryan JF(1).
Author information:
(1)Department of Anatomy and Neuroscience, APC Microbiome Ireland, University
College Cork, Cork, Ireland.
(2)Department of Psychiatry and Neurobehavioural Science, APC Microbiome
Ireland, University College Cork, Cork, Ireland.
The human gut microbiome plays a key role in host physiology in health and
disease. There is a growing emphasis on the bidirectional interaction between
various medications and the gut microbiome. Here, we will first review how drugs
can affect microbiome composition and how the microbiome can alter the
pharmacodynamics and potentially pharmacokinetics of psychotropic medications.
We will take into consideration different classes of psychotropics, including
antipsychotics, antidepressants, antianxiety drugs, anticonvulsants/mood
stabilisers, opioid analgesics, drugs of abuse, alcohol, nicotine, and
xanthines. The varying effects of these widely used medications on
microorganisms are becoming apparent from in vivo and in vitro studies. This has
important implications for future drug discovery in psychiatry which will need
to consider the host microbiome as a major potential target.
© 2021 S. Karger AG, Basel.
DOI: 10.1159/000510423
PMID: 34032649 [Indexed for MEDLINE]