Psychobiology of cocaine addiction: Contribution of a multi-symptomatic animal model of loss of control.
Neuropharmacology. 2014-01-01; 76: 437-449
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1. Neuropharmacology. 2014 Jan;76 Pt B:437-49. doi:
10.1016/j.neuropharm.2013.07.014. Epub 2013 Aug 2.
Psychobiology of cocaine addiction: Contribution of a multi-symptomatic animal
model of loss of control.
Deroche-Gamonet V(1), Piazza PV.
(1)Pathophysiology of Neuronal Plasticity, Neurocentre Magendie, Inserm U862,
University of Bordeaux, 146 rue Léo Saignat, Bordeaux F33077, France. Electronic
Transition to addiction is the shift from controlled to uncontrolled drug use
that occurs after prolonged drug intake in a limited number of drug users. A
major challenge of addiction research in recent years has been to develop models
for studying this pathological transition. Toward this goal, a DSM-IV/5-based
multi-symptomatic model of cocaine addiction has been developed in the rat. It is
based on an operational translation of the main features of the disease. 1.
Addiction is not just taking drug; it is a non-adaptive drug use: The procedure
models addiction in relation to its clinical definition. 2. All drug users do not
face the same individual risk of developing addiction: The model includes an
individual-based approach. 3. Addiction develops after protracted periods of
controlled drug use: This procedure allows for the study of the long-term shift
from controlled drug use to addiction. We describe this model in detail and show
how it can contribute to our understanding of the pathophysiology of cocaine
addiction. This article is part of a Special Issue entitled ‘NIDA 40th
Copyright © 2013. Published by Elsevier Ltd.
PMID: 23916478 [Indexed for MEDLINE]