Pseudoneglect in line bisection judgement is associated with a modulation of right hemispheric spatial attention dominance in right-handers.

Laure Zago, Laurent Petit, Gael Jobard, Julien Hay, Bernard Mazoyer, Nathalie Tzourio-Mazoyer, Hans-Otto Karnath, Emmanuel Mellet
Neuropsychologia. 2017-01-01; 94: 75-83
DOI: 10.1016/j.neuropsychologia.2016.11.024

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1. Neuropsychologia. 2017 Jan 8;94:75-83. doi:
10.1016/j.neuropsychologia.2016.11.024. Epub 2016 Dec 1.

Pseudoneglect in line bisection judgement is associated with a modulation of
right hemispheric spatial attention dominance in right-handers.

Zago L(1), Petit L(2), Jobard G(2), Hay J(2), Mazoyer B(2), Tzourio-Mazoyer N(2),
Karnath HO(3), Mellet E(2).

Author information:
(1)Université de Bordeaux, Institut des Maladies Neurodégénératives, Groupe
d’Imagerie Neurofonctionnelle, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut
des Maladies Neurodégénératives, Groupe d’Imagerie Neurofonctionnelle, UMR 5293,
F-33000 Bordeaux, France; CEA, Institut des Maladies Neurodégénératives, Groupe
d’Imagerie Neurofonctionnelle, UMR 5293, F-33000 Bordeaux, France. Electronic
address: .
(2)Université de Bordeaux, Institut des Maladies Neurodégénératives, Groupe
d’Imagerie Neurofonctionnelle, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut
des Maladies Neurodégénératives, Groupe d’Imagerie Neurofonctionnelle, UMR 5293,
F-33000 Bordeaux, France; CEA, Institut des Maladies Neurodégénératives, Groupe
d’Imagerie Neurofonctionnelle, UMR 5293, F-33000 Bordeaux, France.
(3)Center of Neurology, Division of Neuropsychology, Hertie Institute of Clinical
Brain Research, University of Tübingen, 72076 Tübingen, Germany.

The objective of this study was to validate a line bisection judgement (LBJ) task
for use in investigating the lateralized cerebral bases of spatial attention in a
sample of 51 right-handed healthy participants. Using functional magnetic
resonance imaging (fMRI), the participants performed a LBJ task that was compared
to a visuomotor control task during which the participants made similar saccadic
and motoric responses. Cerebral lateralization was determined using a voxel-based
functional asymmetry analysis and a hemispheric functional lateralization index
(HFLI) computed from fMRI contrast images. Behavioural attentional deviation
biases were assessed during the LBJ task and a « paper and pencil » symbol
cancellation task (SCT). Individual visuospatial skills were also evaluated. The
results showed that both the LBJ and SCT tasks elicited leftward spatial biases
in healthy subjects, although the biases were not correlated, which indicated
their independence. Neuroimaging results showed that the LBJ task elicited a
right hemispheric lateralization, with rightward asymmetries found in a large
posterior occipito-parietal area, the posterior calcarine sulcus (V1p) and the
temporo-occipital junction (TOJ) and in the inferior frontal gyrus, the anterior
insula and the superior medial frontal gyrus. The comparison of the LBJ asymmetry
map to the lesion map of neglect patients who suffer line bisection deviation
demonstrated maximum overlap in a network that included the middle occipital
gyrus (MOG), the TOJ, the anterior insula and the inferior frontal region, likely
subtending spatial LBJ bias. Finally, the LBJ task-related cerebral
lateralization was specifically correlated with the LBJ spatial bias but not with
the SCT bias or with the visuospatial skills of the participants. Taken together,
these results demonstrated that the LBJ task is adequate for investigating
spatial lateralization in healthy subjects and is suitable for determining the
factors underlying the variability of spatial cerebral lateralization.

Copyright © 2017 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.neuropsychologia.2016.11.024
PMID: 27916670 [Indexed for MEDLINE]


Auteurs Bordeaux Neurocampus