Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling.
Neuron. 2011-03-01; 69(6): 1069-1084
DOI: 10.1016/j.neuron.2011.02.018
Lire sur PubMed
1. Neuron. 2011 Mar 24;69(6):1069-84. doi: 10.1016/j.neuron.2011.02.018.
Proneural transcription factors regulate different steps of cortical neuron
migration through Rnd-mediated inhibition of RhoA signaling.
Pacary E(1), Heng J, Azzarelli R, Riou P, Castro D, Lebel-Potter M, Parras C,
Bell DM, Ridley AJ, Parsons M, Guillemot F.
Author information:
(1)Division of Molecular Neurobiology, MRC National Institute for Medical
Research, Mill Hill, London NW7 1AA, UK.
Comment in
Dev Cell. 2011 Apr 19;20(4):409-10.
Little is known of the intracellular machinery that controls the motility of
newborn neurons. We have previously shown that the proneural protein Neurog2
promotes the migration of nascent cortical neurons by inducing the expression of
the atypical Rho GTPase Rnd2. Here, we show that another proneural factor, Ascl1,
promotes neuronal migration in the cortex through direct regulation of a second
Rnd family member, Rnd3. Both Rnd2 and Rnd3 promote neuronal migration by
inhibiting RhoA signaling, but they control distinct steps of the migratory
process, multipolar to bipolar transition in the intermediate zone and locomotion
in the cortical plate, respectively. Interestingly, these divergent functions
directly result from the distinct subcellular distributions of the two Rnd
proteins. Because Rnd proteins also regulate progenitor divisions and neurite
outgrowth, we propose that proneural factors, through spatiotemporal regulation
of Rnd proteins, integrate the process of neuronal migration with other events in
the neurogenic program.
Copyright © 2011 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.neuron.2011.02.018
PMCID: PMC3383999
PMID: 21435554 [Indexed for MEDLINE]