Progressive supranuclear palsy: In vivo SPECT imaging of presynaptic vesicular acetylcholine transporter with [123I]-iodobenzovesamicol
Radiology. 2012-11-01; 265(2): 537-543
DOI: 10.1148/radiol.12112650
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1. Radiology. 2012 Nov;265(2):537-43. doi: 10.1148/radiol.12112650. Epub 2012 Sep
25.
Progressive supranuclear palsy: in vivo SPECT imaging of presynaptic vesicular
acetylcholine transporter with [123I]-iodobenzovesamicol.
Mazère J(1), Meissner WG, Mayo W, Sibon I, Lamare F, Guilloteau D, Tison F,
Allard M.
Author information:
(1)Université de Bordeaux, INCIA, UMR 5287, Talence, France.
PURPOSE: To evaluate the integrity of brain cholinergic pathways in vivo in
patients with progressive supranuclear palsy (PSP) by measuring the vesicular
acetylcholine transporter expression at single photon emission computed
tomography (SPECT) with [123I]-iodobenzovesamicol.
MATERIALS AND METHODS: All participants provided informed written consent
according to institutional human ethics committee guidelines. Ten patients with
PSP and 12 healthy volunteers underwent dynamic [123I]-iodobenzovesamicol SPECT
and magnetic resonance (MR) imaging. CT and MR images were used to register the
dynamic SPECT image to the Montreal Neurologic Institute brain template, which
includes the regions of interest of the striatum and the septo-hippocampal,
innominato-cortical, and ponto-thalamic cholinergic pathways. For each region of
interest, pharmacokinetic modeling of regional time activity curves was used to
calculate [123I]-iodobenzovesamicol to vesicular acetylcholine transporter
binding potential value, proportional to vesicular acetylcholine transporter
expression.
RESULTS: When compared with control participants, patients with PSP had binding
potential values that were unchanged in the striatum and septohippocampal
pathway, significantly lower in the anterior cingulate cortex (P=.017) in the
innominatocortical pathway, and significantly decreased in the thalamus (P=.014)
in the pontothalamic cholinergic pathway. In addition, binding potential values
in the thalamus were positively correlated with those in the pedunculopontine
nucleus (ρ=0.81, P