Preliminary evidence of the cerebellar role on cognitive performances in clinically isolated syndrome.
Journal of the Neurological Sciences. 2018-02-01; 385: 1-6
DOI: 10.1016/j.jns.2017.11.037
Lire sur PubMed
Moroso A(1), Ruet A(1), Lamargue-Hamel D(2), Munsch F(2), Deloire M(3), Ouallet JC(3), Cubizolle S(3), Charré-Morin J(3), Saubusse A(3), Tourdias T(1), Dousset V(1), Brochet B(4).
Author information:
(1)CHU de Bordeaux, INSERM-CHU CIC-P 0005, Service de Neurologie, Bordeaux
F-33076, France; Université de Bordeaux, Bordeaux F-33076, France; Neurocentre
Magendie, INSERM U1215, Team Glia-neuron Interactions, Bordeaux F-33077, France.
(2)Université de Bordeaux, Bordeaux F-33076, France; Neurocentre Magendie, INSERM
U1215, Team Glia-neuron Interactions, Bordeaux F-33077, France.
(3)CHU de Bordeaux, INSERM-CHU CIC-P 0005, Service de Neurologie, Bordeaux
F-33076, France.
(4)CHU de Bordeaux, INSERM-CHU CIC-P 0005, Service de Neurologie, Bordeaux
F-33076, France; Université de Bordeaux, Bordeaux F-33076, France; Neurocentre
Magendie, INSERM U1215, Team Glia-neuron Interactions, Bordeaux F-33077, France.
Electronic address: .
Comment in
J Neurol Sci. 2018 Apr 15;387:92-93.
BACKGROUND: Cerebellar and cognitive dysfunction can occur early in clinically
isolated syndrome (CIS). Eye tracking is a reliable tool for the evaluation of
both subtle cerebellar symptoms and cognitive impairment.
OBJECTIVES: To investigate the early cognitive profile using neuropsychological
and ocular motor (OM) testing in CIS with and without cerebellar dysfunction with
OM testing compared to healthy subjects (HS).
METHODS: Twenty-eight patients and 12 HC underwent OM and neuropsychological
testing. Cerebellar impairment was defined by the registration of saccadic
intrusions and/or at least 10% of dysmetria during ocular motor recording.
Visually guided saccade (VGS), memory-guided saccade (MGS) and antisaccade (AS)
paradigms were compared to neuropsychological assessments.
RESULTS: The group of patients with cerebellar dysfunction (n=16) performed worse
on MGS latencies and error rates, and had worse working memory, executive
function and information processing speed (IPS) z scores than patients without
cerebellar dysfunction. IPS was correlated with the AS error rate in all patients
and with the VGS error rate and the MGS final eye position ratio in cerebellar
patients.
CONCLUSION: Eye tracking is a sensitive tool to assess cognitive and cerebellar
dysfunctions in CIS. In CIS patients, cerebellar impairment is associated with
working memory, executive functions and IPS slowness.