Prefrontal cortex afferents to the anterior temporal lobe in the Macaca fascicularis monkey

Alicia Mohedano-Moriano, Mónica Muñoz-López, Ernesto Sanz-Arigita, Palma Pró-Sistiaga, Alino Martínez-Marcos, María Ester Legidos-Garcia, Ana María Insausti, Sandra Cebada-Sánchez, María Del Mar Arroyo-Jiménez, Pilar Marcos, Emilio Artacho-Pérula, Ricardo Insausti
J. Comp. Neurol.. 2015-07-07; 523(17): 2570-2598
DOI: 10.1002/cne.23805

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1. J Comp Neurol. 2015 Dec 1;523(17):2570-98. doi: 10.1002/cne.23805. Epub 2015 Jul

Prefrontal cortex afferents to the anterior temporal lobe in the Macaca
fascicularis monkey.

Mohedano-Moriano A(1), Muñoz-López M(1), Sanz-Arigita E(2), Pró-Sistiaga P(3),
Martínez-Marcos A(4), Legidos-Garcia ME(1), Insausti AM(5), Cebada-Sánchez S(1),
Arroyo-Jiménez Mdel M(1), Marcos P(1), Artacho-Pérula E(1), Insausti R(1).

Author information:
(1)Department of Health Sciences, University of Castilla-La Mancha, Albacete,
02006, Spain.
(2)Radiology and Image Analysis Center – Free University Medical center (VUmc),
Amsterdam, The Netherlands.
(3)UNICAEN, UMS 3408, GIP Cyceron, Campus Jules Horowiz, 1474, Caen, France.
(4)Department of Health Sciences, University of Castilla-La Mancha, Ciudad Real,
13071, Spain.
(5)Department of Health, Physical Therapy School, Public University of Navarre,
Tudela Campus, 31005, Tudela, Spain.

The anatomical organization of the lateral prefrontal cortex (LPFC) afferents to
the anterior part of the temporal lobe (ATL) remains to be clarified. The LPFC
has two subdivisions, dorsal (dLPFC) and ventral (vLPFC), which have been linked
to cognitive processes. The ATL includes several different cortical areas,
namely, the temporal polar cortex and rostral parts of the perirhinal,
inferotemporal, and anterior tip of the superior temporal gyrus cortices.
Multiple sensory modalities converge in the ATL. All of them (except the rostral
inferotemporal and superior temporal gyrus cortices) are components of the medial
temporal lobe, which is critical for long-term memory processing. We studied the
LPFC connections with the ATL by placing retrograde tracer injections into the
ATL: the temporal polar (n = 3), perirhinal (areas 35 and 36, n = 6), and
inferotemporal cortices (area TE, n = 5), plus one additional deposit in the
posterior parahippocampal cortex (area TF, n = 1). Anterograde tracer deposits
into the dLPFC (A9 and A46, n = 2), the vLPFC (A46v, n = 2), and the
orbitofrontal cortex (OF; n = 2) were placed for confirmation of those
projections. The results showed that the vLPFC displays a moderate projection to
rostral area TE and the dorsomedial portion of the temporal polar cortex; in
contrast, the dLPFC connections with the ATL were weak. By comparison, the OFC
and medial frontal cortices (MFC) showed dense connectivity with the ATL, namely,
A13 with the temporopolar and perirhinal cortices. All areas of the MFC projected
to the temporopolar cortex, albeit with a lower intensity. The functional
significance of such paucity of LPFC afferents is unknown.

© 2015 Wiley Periodicals, Inc.

DOI: 10.1002/cne.23805
PMID: 25975699 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus