Posterior lobules of the cerebellum and information processing speed at various stages of multiple sclerosis.

Amandine Moroso, Aurélie Ruet, Delphine Lamargue-Hamel, Fanny Munsch, Mathilde Deloire, Pierrick Coupé, Jean-Christophe Ouallet, Vincent Planche, Nicolas Moscufo, Dominik S Meier, Thomas Tourdias, Charles R G Guttmann, Vincent Dousset, Bruno Brochet
J Neurol Neurosurg Psychiatry. 2016-10-27; 88(2): 146-151
DOI: 10.1136/jnnp-2016-313867

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1. J Neurol Neurosurg Psychiatry. 2017 Feb;88(2):146-151. doi:
10.1136/jnnp-2016-313867. Epub 2016 Oct 27.

Posterior lobules of the cerebellum and information processing speed at various
stages of multiple sclerosis.

Moroso A(1)(2)(3), Ruet A(1)(2)(3), Lamargue-Hamel D(1)(3), Munsch F(1)(3),
Deloire M(2), Coupé P(1)(4), Ouallet JC(2), Planche V(1)(3), Moscufo N(5), Meier
DS(5), Tourdias T(1)(2)(3), Guttmann CR(5), Dousset V(1)(2)(3), Brochet

Author information:
(1)University Bordeaux, Bordeaux, France.
(2)Services de Neurologie et Neuroradiologie, CHU de Bordeaux, INSERM-CHU CIC-P
0005, Bordeaux, France.
(3)Neurocentre Magendie, INSERM U1215, Bordeaux, France.
(4)LaBRI, UMR 5800, PICTURA, Talence, France.
(5)Department of Radiology, Center for Neurological Imaging, Brigham and Women’s
Hospital, Harvard Medical School, Boston, Massachusetts, USA.

BACKGROUND: Cerebellar damage has been implicated in information processing speed
(IPS) impairment associated with multiple sclerosis (MS) that might result from
functional disconnection in the frontocerebellar loop. Structural alterations in
individual posterior lobules, in which cognitive functioning seems preponderant,
are still unknown. Our aim was to investigate the impact of grey matter (GM)
volume alterations in lobules VI to VIIIb on IPS in persons with clinically
isolated syndrome (PwCIS), MS (PwMS) and healthy subjects (HS).
METHODS: 69 patients (37 PwCIS, 32 PwMS) and 36 HS underwent 3 T MRI including
3-dimensional T1-weighted MRIs. Cerebellum lobules were segmented using SUIT
V.3.0 to estimate their normalised GM volume. Neuropsychological testing was
performed to assess IPS and main cognitive functions.
RESULTS: Normalised GM volumes were significantly different between PwMS and HS
for the right (p

Auteurs Bordeaux Neurocampus