Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance: a bicentric double-blind, randomized, placebo-controlled clinical study.
The Journals of Gerontology: Series A. 2018-07-19; :
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Polyphenols from grape and blueberry improve episodic memory in healthy elderly
with lower level of memory performance: a bicentric double-blind, randomized,
placebo-controlled clinical study.
Bensalem J(1)(2)(3), Dudonné S(4)(5), Etchamendy N(1)(2), Pellay H(1)(2)(3),
Amadieu C(1)(2), Gaudout D(3), Dubreuil S(3), Paradis ME(4)(5), Pomerleau S(4),
Capuron L(1)(2)(5), Hudon C(4)(6), Layé S(1)(2)(5), Desjardins Y(4)(5), Pallet
(1)Univ. de Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux,
(2)INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France.
(3)Activ’Inside, Beychac et Caillau, France.
(4)Institute of Nutrition and Functional Foods (INAF), Laval University, Québec,
(5)OptiNutriBrain International Associated Laboratory (NutriNeuro France-INAF
Canada), Bordeaux, France.
(6)Centre de recherche de l’Institut universitaire en santé mentale de Québec,
(7)Bordeaux INP, Nutrition et neurobiologie intégrée, UMR1286, Bordeaux, France.
Polyphenols are promising nutritional bioactives exhibiting beneficial effect on
age-related cognitive decline. The present study evaluated the effect of a
polyphenol-rich extract from grape and blueberry (PEGB) on memory of healthy
elderly subjects (60-70 years-old). A bicentric, randomized, double-blind,
placebo-controlled trial was conducted with 215 volunteers receiving 600 mg/day
of PEGB (containing 258 mg flavonoids) or a placebo for 6 months. The primary
outcome was the CANTAB Paired Associate Learning (PAL), a visuospatial learning
and episodic memory test. Secondary outcomes included verbal episodic and
recognition memory (VRM) and working memory (SSP). There was no significant
effect of PEGB on the PAL on the whole cohort. Yet, PEGB supplementation improved
VRM free recall. Stratifying the cohort in quartiles based on PAL at baseline
revealed a subgroup with advanced cognitive decline (decliners) who responded
positively to the PEGB. In this group, PEGB consumption was also associated with
a better VRM delayed recognition. In addition to a lower polyphenol consumption,
the urine metabolomic profile of decliners revealed that they excreted more
metabolites. Urinary concentrations of specific flavan-3-ols metabolites were
associated, at the end of the intervention, with the memory improvements. Our
study demonstrates that PEGB improves age-related episodic memory decline in
individuals with the highest cognitive impairments.