Physiological significance of the interleukin 1 receptor accessory protein
Neuroimmunomodulation. 2001-01-01; 9(4): 225-230
DOI: 10.1159/000049030
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1. Neuroimmunomodulation. 2001;9(4):225-30.
Physiological significance of the interleukin 1 receptor accessory protein.
Layé S(1), Liège S, Li KS, Moze E, Neveu PJ.
Author information:
(1)Laboratoire de Neurocytochimie Fonctionnelle, Université de Bordeaux I,
Talence, France.
Interleukin 1 receptor accessory protein (IL-1RAcP) is an essential
signal-transducing component of the IL-1 receptor type I. The recent availability
of IL-1RAcP-deficient (KO) mice allows to study the in vivo function of IL-1RAcP.
Animals were injected intraperitoneally with rat recombinant IL-1beta (200
ng/mouse), lipopolysaccharide (LPS, 5 microg/mouse), or subjected to 1-hour
restraint stress. Neuroendocrine and immune parameters were measured 2 h after
IL-1 or LPS injection or just after restraint. In wild-type controls, IL-1 and
LPS activated the hypothalamic-pituitary-adrenal axis and increased plasma IL-6.
In KO mice, the plasma levels of corticosterone and IL-6 increased after LPS, but
not after rat recombinant IL-1beta. The LPS-induced depression of the
lymphoproliferation was similar in wild-type and KO mice. Finally, the 1-hour
restraint was able to increase the plasma levels of corticosterone in KO mice.
These results show that IL-1RAcP is essential for physiological activities of
peripheral IL-1, as it was previously demonstrated for those of brain IL-1.
However, using IL-1RAcP KO mice, we were unable to demonstrate a specific role of
endogenous IL-1 during LPS-induced inflammation. Moreover, stress-induced
activation of the hypothalamic-pituitary-adrenal axis may occur in the absence of
the IL-1-transducing receptor, IL-1RAcP.
Copyright 2002 S. Karger AG, Basel
DOI: 10.1159/000049030
PMID: 11847485 [Indexed for MEDLINE]