Pharmacological studies of proctolin receptors on foregut and hindgut of blaberus craniifer
Peptides. 1998-01-01; 19(10): 1641-1651
DOI: 10.1016/s0196-9781(98)00120-x
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https://www.bordeaux-neurocampus.fr/12206
1. Peptides. 1998;19(10):1641-51. doi: 10.1016/s0196-9781(98)00120-x.
Pharmacological studies of proctolin receptors on foregut and hindgut of
Blaberus craniifer.
Mazzocco-Manneval C(1), Kuczer M, Konopinska D, Fournier B, Loughton BG, Puiroux
J.
Author information:
(1)Laboratoire de Neuroendocrinologie de l’insecte, ER CNRS 629, Université
Bordeaux I, France.
Proctolin (Arg-Tyr-Leu-Pro-Thr) and proctolin analogs modified at position 1, 2,
or 5 caused dose dependent contractions of Blaberus fore- and hindgut. The
varying contractile effects between both tissues revealed the possible presence
of receptor subtypes as identified by [GABA1]-proctolin. A single population of
binding sites (Kd approximately 100 nM) was deduced from Scatchard analysis. In
addition, nanomolar concentrations of proctolin induced a dose-dependent
hydrolysis of phosphoinositides (PIns) augmented by GTPgammaS (1 microM) on
foregut membranes but no accumulation of cAMP. Proctolin induced contractions
are likely mediated via a phospholipase C linked to a heptahelical receptor
bound to heterotrimeric G-proteins.
DOI: 10.1016/s0196-9781(98)00120-x
PMID: 9880067 [Indexed for MEDLINE]