Patterns of brain atrophy associated with episodic memory and semantic fluency decline in aging.
Aging. 2017-03-09; 9(3): 741-752
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1. Aging (Albany NY). 2017 Mar 9;9(3):741-752. doi: 10.18632/aging.101186.
Patterns of brain atrophy associated with episodic memory and semantic fluency
decline in aging.
Pelletier A(1)(2), Bernard C(3)(4), Dilharreguy B(3)(4), Helmer C(1)(2), Le Goff
M(1)(2), Chanraud S(3)(4)(5), Dartigues JF(1)(2), Allard M(3)(4)(5)(6), Amieva
H(1)(2), Catheline GW(3)(4)(5).
(1)University Bordeaux, ISPED, Centre INSERM U1219, F-33000 Bordeaux, France.
(2)INSERM, ISPED, Centre INSERM U1219, F-33000 Bordeaux, France.
(3)University Bordeaux, INCIA, UMR 5287, F-33000 Bordeaux, France.
(4)CNRS, INCIA, UMR 5287, F-33000 Bordeaux, France.
(5)EPHE, PSL Research University, F-33000 Bordeaux, France.
(6)CHU de Bordeaux, F-33000 Bordeaux, France.
Aging (Albany NY). 2017 May 16;9(5):1470.
The cerebral substratum of age-related cognitive decline was evaluated in an
elderly-cohort followed for 12 years (n=306). Participants, free of dementia,
received neuropsychological assessments every two years and an MRI exam at
baseline and four years later. Cognitive decline was evaluated on two broadly
used tests to detect dementia: the Free and Cued Selective Reminding Test
(FCSRT), a verbal episodic memory task, and the Isaacs Set Test (IST), a semantic
fluency task. Using voxel-based approach, the relationship between cognitive
decline with 1/ baseline grey matter volumes and 2/ grey matter volume loss
between the two scans was explored. Baseline volumes analysis revealed that FCSRT
and IST declines were both associated with lower volumes of the medial temporal
region. Volumes loss analysis confirmed that both declines are related to medial
temporal lobe atrophy and revealed that FCSRT decline was specifically associated
with atrophy of the posterior cingulate cortex whereas IST decline was
specifically related to temporal pole atrophy. These results suggest that
cognitive decline across aging is firstly related to structural modifications of
the medial temporal lobe, followed by an atrophy in the posterior midline
structures for episodic memory and an atrophy of the temporal pole for semantic
PMID: 28278492 [Indexed for MEDLINE]