Pattern separation performance is decreased in patients with early multiple sclerosis.
Brain Behav. 2017-06-21; 7(8): e00739
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1. Brain Behav. 2017 Jun 21;7(8):e00739. doi: 10.1002/brb3.739. eCollection 2017
Pattern separation performance is decreased in patients with early multiple
Planche V(1)(2)(3), Ruet A(1)(2)(4), Charré-Morin J(4), Deloire M(4), Brochet
B(1)(2)(4), Tourdias T(1)(2)(4).
(1)University of BordeauxBordeauxFrance.
(2)Neurocentre MagendieInserm U1215BordeauxFrance.
(3)CHU de Clermont-FerrandClermont-FerrandFrance.
(4)CHU de BordeauxBordeauxFrance.
BACKGROUND: Hippocampal-dependent memory impairment is frequent and occurs early
during the course of multiple sclerosis (MS). While mechanisms responsible for
episodic memory dysfunction in patients with MS remain largely unknown, dentate
gyrus structure has been suggested as particularly vulnerable at the early stage
of the disease. If true, we hypothesized that the pattern separation component of
episodic memory (a function known to be critically dependent to dentate gyrus
function) would be impaired in patients with early MS (PweMS).
METHODS: Thirty eight participants (19 PweMS and 19 healthy controls matched on
age, gender and education level) were tested with a behavioral pattern separation
task and also for information processing speed and visuospatial episodic memory.
RESULTS: We report a significant decrease in pattern separation performance in
PweMS compared to healthy controls (27.07 vs. 40.01, p = .030 after
Holm-Bonferroni correction, d = 1.02) together with a significantly higher
pattern completion rate (56.11 vs. 40.95, p = .004 after Holm-Bonferroni
correction, d = 1.07) while no difference was found among groups for information
processing speed and « global » visuospatial episodic memory regarding learning,
long-term recall or recognition.
CONCLUSION: Our results suggest that behavioral pattern separation task can
detect subtle memory decline in patients with MS and argue for early dentate
gyrus dysfunction during the course of the disease.
PMID: 28828205 [Indexed for MEDLINE]