Parkinson’s disease: convergence on synaptic homeostasis
EMBO J.. 2018-07-31; 37(18): e98960
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1. EMBO J. 2018 Sep 14;37(18). pii: e98960. doi: 10.15252/embj.201898960. Epub 2018
Parkinson’s disease: convergence on synaptic homeostasis.
Soukup SF(1)(2), Vanhauwaert R(3)(2), Verstreken P(1)(2).
(1)VIB-KU Leuven Center for Brain& Disease Research, Leuven, Belgium
(2)Department of Neurosciences, KU Leuven, Leuven, Belgium.
(3)VIB-KU Leuven Center for Brain& Disease Research, Leuven, Belgium.
Parkinson’s disease, the second most common neurodegenerative disorder, affects
millions of people globally. There is no cure, and its prevalence will double by
2030. In recent years, numerous causative genes and risk factors for Parkinson’s
disease have been identified and more than half appear to function at the
synapse. Subtle synaptic defects are thought to precede blunt neuronal death, but
the mechanisms that are dysfunctional at synapses are only now being unraveled.
Here, we review recent work and propose a model where different Parkinson
proteins interact in a cell compartment-specific manner at the synapse where
these proteins regulate endocytosis and autophagy. While this field is only
recently emerging, the work suggests that the loss of synaptic homeostasis may
contribute to neurodegeneration and is a key player in Parkinson’s disease.
© 2018 The Authors.
PMCID: PMC6138432 [Available on 2019-09-14]