Parieto-temporal alpha EEG band power at baseline as a predictor of antidepressant treatment response with repetitive transcranial magnetic stimulation: A preliminary study
Journal of Affective Disorders. 2012-03-01; 137(1-3): 156-160
DOI: 10.1016/j.jad.2011.12.030
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1. J Affect Disord. 2012 Mar;137(1-3):156-60. doi: 10.1016/j.jad.2011.12.030. Epub
2012 Jan 12.
Parieto-temporal alpha EEG band power at baseline as a predictor of
antidepressant treatment response with repetitive Transcranial Magnetic
Stimulation: a preliminary study.
Micoulaud-Franchi JA(1), Richieri R, Cermolacce M, Loundou A, Lancon C, Vion-Dury
J.
Author information:
(1)Pôle de Psychiatrie Solaris, Centre Hospitalier Universitaire de
Sainte-Marguerite, 270 Boulevard de Sainte-Marguerite, Marseille, France.
BACKGROUND: The aim of this preliminary study was to determine the predictive
value of absolute alpha band power measured during the rest EEG eyes closed task
for responses to 20 sessions of high frequency repetitive transcranial
stimulation (rTMS) in the left dorsolateral prefrontal cortex in patients with
pharmacoresistant major depressive episode.
METHODS: 13 major depressive disorders (8 males) and 8 bipolar disorders (6
males) were included (mean age 58years). Spearman correlations between
pretreatment alpha band power in height regions of analysis and absolute
improvement in Beck Depression Inventory Short Form (ΔBDI-SF) were analyzed. The
predictive value of alpha band power for classifying patients as responders and
non-responders to rTMS was determined using Receiver Operating Characteristic
(ROC) curve.
RESULTS: Spearman correlation analysis revealed that ΔBDI-SF correlated
significantly and negatively with alpha band power on the right (r=-.673, p=.001)
and left parieto-temporal regions (r=-.638, p=.002). The area under the ROC curve
for the right parieto-temporal was .815, p=.0037. The cut-off point that
maximized both sensitivity and specificity was 1.49μV. Sensitivity, specificity,
positive and negative predictive values were 100, 66, 80, 100% respectively.
LIMITATIONS: The population was small and lacked homogeneity concerning affective
disorders (unipolar and bipolar disorder). The use of a self-rating subjective
scale (BDI-SF) to measure the severity of depression could be criticized.
CONCLUSIONS: Pretreatment alpha band power on parieto-temporal regions could be a
predictor for response to rTMS in patients with homogenous demographic/clinical
features. The association between electrical activity and the perfusion under
each electrode need to be examined.
Copyright © 2011 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.jad.2011.12.030
PMID: 22244378 [Indexed for MEDLINE]