Optic Radiations Microstructural Changes in Glaucoma and Association With Severity: A Study Using 3Tesla-Magnetic Resonance Diffusion Tensor Imaging.
Invest. Ophthalmol. Vis. Sci.. 2016-12-01; 57(15): 6539
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1. Invest Ophthalmol Vis Sci. 2016 Dec 1;57(15):6539-6547. doi:
Optic Radiations Microstructural Changes in Glaucoma and Association With
Severity: A Study Using 3Tesla-Magnetic Resonance Diffusion Tensor Imaging.
Tellouck L(1), Durieux M(2), Coupé P(3), Cougnard-Grégoire A(4), Tellouck J(5),
Tourdias T(6), Munsch F(2), Garrigues A(5), Helmer C(4), Malet F(7), Dartigues
JF(4), Dousset V(6), Delcourt C(4), Schweitzer C(1).
(1)CHU de Bordeaux, Service d’Ophtalmologie, Bordeaux, France 2University of
Bordeaux, Bordeaux, France 3INSERM, U1219-Bordeaux Population Health Research
Center, Bordeaux, France.
(2)CHU de Bordeaux, Service de Neuro-Imagerie, Bordeaux, France.
(3)Université de Bordeaux, LaBRI, UMR 5800, PICTURA, Talence, France 6CNRS,
LaBRI, UMR 5800, PICTURA, Talence, France.
(4)University of Bordeaux, Bordeaux, France 3INSERM, U1219-Bordeaux Population
Health Research Center, Bordeaux, France.
(5)CHU de Bordeaux, Service d’Ophtalmologie, Bordeaux, France.
(6)University of Bordeaux, Bordeaux, France 4CHU de Bordeaux, Service de
Neuro-Imagerie, Bordeaux, France 7INSERM, U1215, Neurocentre Magendie, Bordeaux,
(7)Centre d’Ophtalmologie Point Vision, Bordeaux, France.
Purpose: To compare microstructural changes along the optical radiations and
brain structure volumes between glaucoma and control subjects using in vivo
magnetic resonance imaging and to analyze their association with severity of the
Methods: A total of 50 open-angle glaucoma subjects and 50 healthy age- and
sex-matched controls underwent detailed ophthalmologic examinations (including
visual field testing [VF], funduscopy, and spectral-domain optical coherence
tomography) as well as diffusion tensor imaging (DTI) using 3.0-Tesla magnetic
resonance imaging. Fractional anisotropy (FA), mean diffusivity, radial
diffusivity (RD), and axial diffusivity (AD) were quantified semiautomatically
along the optical radiations. DTI parameters and volumes of specific brain
structures were compared between cases and controls using conditional logistic
regression. Association between DTI metrics and the severity of the disease was
studied using linear mixed regression analyses.
Results: In glaucoma subjects, optic radiations FA was significantly lower (0.57
vs. 0.59; P = 0.02) and RD was significantly higher (52.78 10-5 mm2/s vs. 49.74
10-5 mm2/s; P = 0.03) than in controls. Optic radiations FA was significantly
correlated with homolateral functional and structural damage of glaucoma (mean
deviation of VF [P = 0.03], retinal nerve fiber layer thickness [P = 0.03],
vertical cup to disc ratio [P = 0.0007]). Volume and DTI parameters of other
brain structures (including hippocampus) were not significantly different between
glaucoma patients and controls.
Conclusions: We evidenced microstructural modifications along visual pathways of
glaucoma patients and these alterations were correlated with disease severity.
The association of glaucoma with other neurodegenerative alterations would need
further exploration and a prospective follow-up of our cohort of subjects.
(ClinicalTrials.gov number, NCT01621841).
PMID: 27918827 [Indexed for MEDLINE]