Operation and plasticity of hippocampal CA3 circuits: Implications for memory encoding
Nat Rev Neurosci. 2017-03-02; 18(4): 208-220
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1. Nat Rev Neurosci. 2017 Apr;18(4):208-220. doi: 10.1038/nrn.2017.10. Epub 2017 Mar
Operation and plasticity of hippocampal CA3 circuits: implications for memory
Rebola N(1), Carta M(1), Mulle C(1).
(1)University of Bordeaux, Interdisciplinary Institute for Neuroscience, Centre
National de la Recherche Scientifique (CNRS), F-33000 Bordeaux, France.
The CA3 region of the hippocampus is important for rapid encoding of memory.
Computational theories have proposed specific roles in hippocampal function and
memory for the sparse inputs from the dentate gyrus to CA3 and for the extended
local recurrent connectivity that gives rise to the CA3 autoassociative network.
Recently, we have gained considerable new insight into the operation and
plasticity of CA3 circuits, including the identification of novel forms of
synaptic plasticity and their underlying mechanisms, and structural plasticity in
the GABAergic control of CA3 circuits. In addition, experimental links between
synaptic plasticity of CA3 circuits and memory are starting to emerge.
PMID: 28251990 [Indexed for MEDLINE]