One step closer to a global tool for rapid screening of major depression in epilepsy: Validation of the French NDDI-E

Jean-Arthur Micoulaud-Franchi, Gérald Barkate, Agnès Trébuchon-Da Fonseca, Lisa Vaugier, Martine Gavaret, Fabrice Bartolomei, Aileen McGonigal
Epilepsy & Behavior. 2015-03-01; 44: 11-16
DOI: 10.1016/j.yebeh.2014.12.011

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1. Epilepsy Behav. 2015 Mar;44:11-6. doi: 10.1016/j.yebeh.2014.12.011. Epub 2015 Jan
16.

One step closer to a global tool for rapid screening of major depression in
epilepsy: validation of the French NDDI-E.

Micoulaud-Franchi JA(1), Barkate G(2), Trébuchon-Da Fonseca A(3), Vaugier L(4),
Gavaret M(3), Bartolomei F(5), McGonigal A(6).

Author information:
(1)Pôle de Psychiatrie « Solaris », Centre Hospitalier Universitaire de
Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France;
Laboratoire de Neurosciences Cognitives, UMR CNRS 7291, 31 Aix-Marseille
Université, 13331 Marseille, France.
(2)Hôpital Henri Gastaut, Etablissement Hospitalier Spécialisé dans le traitement
des Epilepsies, 300 Boulevard de Sainte-Marguerite, 13009 Marseille, France.
(3)Service de Neurophysiologie Clinique, APHM, Hôpital de la Timone, 13005
Marseille, France; INSERM UMR 1106, INS, 27 Bd Jean Moulin, 13385 Marseille,
France; Aix Marseille Université, Faculté de Médecine, Marseille, France.
(4)Service de Neurophysiologie Clinique, APHM, Hôpital de la Timone, 13005
Marseille, France; Service de Neurophysiologie Clinique, APHM, Hôpital Nord,
13015 Marseille, France.
(5)Service de Neurophysiologie Clinique, APHM, Hôpital de la Timone, 13005
Marseille, France; INSERM UMR 1106, INS, 27 Bd Jean Moulin, 13385 Marseille,
France; Aix Marseille Université, Faculté de Médecine, Marseille, France; Hôpital
Henri Gastaut, Etablissement Hospitalier Spécialisé dans le traitement des
Epilepsies, 300 Boulevard de Sainte-Marguerite, 13009 Marseille, France.
(6)Service de Neurophysiologie Clinique, APHM, Hôpital de la Timone, 13005
Marseille, France; INSERM UMR 1106, INS, 27 Bd Jean Moulin, 13385 Marseille,
France; Aix Marseille Université, Faculté de Médecine, Marseille, France.
Electronic address: .

OBJECTIVE: Depression in people with epilepsy (PWE) is underdiagnosed and
undertreated. The Neurological Disorders Depression Inventory for Epilepsy
(NDDI-E) is a screening questionnaire used for detecting major depressive episode
(MDE) in PWE, and is already validated in 10 languages. However a version in
French, one of the world’s widely spoken languages, was, until now, lacking. We
aimed to translate and validate the French NDDI-E.
METHODS: This study was performed under the auspices of the ILAE. People with
epilepsy >18years of age were recruited from 2 specialist epilepsy units in
Marseille, France. Two native French speakers and 2 native English speakers
performed a forward-backward translation. The Mini International Neuropsychiatric
Interview (MINI) was performed as the gold standard, and the Center for
Epidemiological Studies Depression symptoms index (CES-D) was performed for
external validity. Data were compared between PWE with MDE and PWE without MDE
using the chi-square test and Student’s t-test. Internal structural validity,
external validity, and receiver operator characteristics were analyzed.
RESULTS: Testing was performed on 116 PWE: mean age=40.39years (SD=13.83, range:
[18-81]years old); 58.6% (68) were women; 87.1% had focal epilepsy. Using the
MINI, we found that 33 (28.4%) patients had current MDE and that 15 (12.9%)
patients had dysthymia; also, we found that 37 (31.9%) patients presented
suicidal ideation and/or behavior. Cronbach’s alpha coefficient was 0.838,
indicating satisfactory internal consistency. Correlation between the NDDI-E and
the CES-D scores was high (r(116)=0.817, p

Auteurs Bordeaux Neurocampus