Novel characterization of the relationship between verbal list‐learning outcomes and hippocampal subfields in healthy adults

Sandrine Cremona, Laure Zago, Emmanuel Mellet, Laurent Petit, Alexandre Laurent, Antonietta Pepe, Ami Tsuchida, Naka Beguedou, Marc Joliot, Christophe Tzourio, Bernard Mazoyer, Fabrice Crivello
Hum Brain Mapp. 2021-08-28; :
DOI: 10.1002/hbm.25614

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Cremona S(1), Zago L(1), Mellet E(1), Petit L(1), Laurent A(1), Pepe A(1), Tsuchida A(1), Beguedou N(1), Joliot M(1), Tzourio C(2), Mazoyer B(1)(3),
Crivello F(1).

Author information:
(1)Université de Bordeaux – Neurocampus, CEA, CNRS, IMN UMR 5293, Bordeaux, France.
(2)Université de Bordeaux – Département Santé publique, INSERM, BPH U 1219, Bordeaux, France.
(3)Institut des maladies neurodégénératives clinique, CHU de Bordeaux, Bordeaux, France.

The relationship between hippocampal subfield volumetry and verbal list-learning test outcomes have mostly been studied in clinical and elderly populations, and remain controversial. For the first time, we characterized a relationship between verbal list-learning test outcomes and hippocampal subfield volumetry on two large separate datasets of 447 and 1,442 healthy young and middle-aged adults,
and explored the processes that could explain this relationship. We observed a replicable positive linear correlation between verbal list-learning test free recall scores and CA1 volume, specific to verbal list learning as demonstrated by the hippocampal subfield volumetry independence from verbal intelligence. Learning meaningless items was also positively correlated with CA1 volume, pointing to the role of the test design rather than word meaning. Accordingly, we found that association-based mnemonics mediated the relationship between verbal
list-learning test outcomes and CA1 volume. This mediation suggests that integrating items into associative representations during verbal list-learning tests explains CA1 volume variations: this new explanation is consistent with the associative functions of the human CA1.

© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.


Auteurs Bordeaux Neurocampus