Noncanonical Wnt signaling and neural polarity.

Mireille Montcouquiol, E. Bryan Crenshaw, Matthew W. Kelley
Annu. Rev. Neurosci.. 2006-07-21; 29(1): 363-386
DOI: 10.1146/annurev.neuro.29.051605.112933

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1. Annu Rev Neurosci. 2006;29:363-86.

Noncanonical Wnt signaling and neural polarity.

Montcouquiol M(1), Crenshaw EB 3rd, Kelley MW.

Author information:
(1)Section on Developmental Neuroscience, NIDCD, NIH, Bethesda, Maryland 20982,

The Wnt signaling pathway regulates multiple events in development and disease in
both vertebrates and invertebrates. Recently, the noncanonical Wnt signaling
cascades, those that do not signal through beta-catenin, have gained prominence
for their role in the regulation of cellular polarity. It is not surprising that
cellular polarization influences a number of different developmental events
within the nervous system, including neurulation and neural tube closure,
cellular migration, and uniform orientation of cells within an epithelial plane
(planar cell polarity). In this review, we describe the differences between the
canonical and noncanonical pathways, summarize recent data illustrating the roles
of the noncanonical Wnt pathway in different polarizing events during neural
development, and discuss the potential molecular mechanisms that underlie the
generation of cellular asymmetry and polarity.

DOI: 10.1146/annurev.neuro.29.051605.112933
PMID: 16776590 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus