Neuropeptide tyrosine and pain
Trends in Pharmacological Sciences. 2007-02-01; 28(2): 93-102
DOI: 10.1016/j.tips.2006.12.003
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1. Trends Pharmacol Sci. 2007 Feb;28(2):93-102. Epub 2007 Jan 11.
Neuropeptide tyrosine and pain.
Brumovsky P(1), Shi TS, Landry M, Villar MJ, Hökfelt T.
Author information:
(1)Department of Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden.
Research during the past two decades supports a complex role for neuropeptide
tyrosine (NPY) and two of its associated receptors, the Y1 receptor and the Y2
receptor, in the modulation of pain, in addition to regeneration and survival
mechanisms at the spinal level. Thus, NPY has been shown to both cause and reduce
pain, in addition to having biphasic effects. Recent research has focused on the
distribution of the spinal NPY-mediated system. Here, we propose various possible
scenarios for the role of NPY in pain processing, based on its actions at
different sites (axon versus cell body), through different receptors (Y1 receptor
versus Y2 receptor) and/or types of neuron (ganglion neurons and intraganglionic
cross-excitation versus interneurons versus projection neurons).
DOI: 10.1016/j.tips.2006.12.003
PMID: 17222466 [Indexed for MEDLINE]