Neuronal activity determines the protein synthesis dependence of long-term potentiation

Rosalina Fonseca, U Valentin Nägerl, Tobias Bonhoeffer
Nat Neurosci. 2006-03-12; 9(4): 478-480
DOI: 10.1038/nn1667

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1. Nat Neurosci. 2006 Apr;9(4):478-80. Epub 2006 Mar 12.

Neuronal activity determines the protein synthesis dependence of long-term
potentiation.

Fonseca R(1), Nägerl UV, Bonhoeffer T.

Author information:
(1)Department of Cellular and Systems Neurobiology, Max Planck Institute of
Neurobiology, Am Klopferspitz 18, D-82152 München-Martinsried, Germany.

Long-term potentiation (LTP) is generally divided into two phases, early (E-) and
late (L-) LTP, of which only L-LTP is thought to depend on protein synthesis.
Here we report that E-LTP can also be dependent on protein synthesis at higher
levels of synaptic activation. Moreover, we show that the requirement for protein
synthesis during L-LTP extends beyond the early induction phase and that it
depends on synaptic stimulation. This suggests that the level of neuronal
activity is a crucial determinant for the role of protein synthesis in E- and
L-LTP.

DOI: 10.1038/nn1667
PMID: 16531998 [Indexed for MEDLINE]


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