Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects?
Neurochemistry International. 2015-10-01; 89: 63-74
DOI: 10.1016/j.neuint.2015.08.004
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1. Neurochem Int. 2015 Oct;89:63-74. doi: 10.1016/j.neuint.2015.08.004. Epub 2015
Aug 7.
Neuroinflammatory processes in cognitive disorders: Is there a role for
flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental
effects?
Vauzour D(1), Martinsen A(2), Layé S(3).
Author information:
(1)Norwich Medical School, Faculty of Medicine and Health Sciences, University of
East Anglia, Norwich NR4 7UQ, United Kingdom. Electronic address:
.
(2)Norwich Medical School, Faculty of Medicine and Health Sciences, University of
East Anglia, Norwich NR4 7UQ, United Kingdom.
(3)INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France;
Bordeaux University, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux,
France. Electronic address: .
Neuroinflammatory processes are known to contribute to the cascade of events
culminating in the neuronal damage that underpins neurodegenerative disorders
such as Parkinson’s and Alzheimer’s disease. With the ageing population and
increased cases of neurodegenerative diseases, there is a crucial need for the
development of new strategies capable to prevent, delay the onset or treat brain
dysfunction and associated cognitive decline. Growing evidence sheds light on the
use of dietary polyphenols and n-3 long chain polyunsaturated fatty acids to
improve cognitive performance and reduce the neuroinflammatory and oxidative
stress responses occurring with age and neurodegenerative pathologies. This
review will summarise the most recent information related to the impact and
mechanisms underlying the neuroinflammatory processes in neurodegenerative
disorders. We will also detail the current evidence indicating that flavonoids
and n-3 polyunsaturated fatty acids are strong candidates in preventing
neuroinflammation and modulating age-related memory decline, and we will describe
the potential mechanisms of action underlying their neuroprotective effects. As
such, these dietary bioactives represent important precursor molecules in the
quest to develop a new generation of drugs capable of counteracting
neuroinflammation and neurodegenerative diseases.
Copyright © 2015 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.neuint.2015.08.004
PMID: 26260547 [Indexed for MEDLINE]