Natural speech comprehension in bipolar disorders: an event-related brain potential study among manic patients.

Michel Cermolacce, Mélanie Faugère, Jean-Arthur Micoulaud-Franchi, Raoul Belzeaux, Muriel Maurel, Jean Naudin, Jean-Michel Azorin, Jean Vion-Dury
Journal of Affective Disorders. 2014-04-01; 158: 161-171
DOI: 10.1016/j.jad.2013.11.013

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1. J Affect Disord. 2014 Apr;158:161-71. doi: 10.1016/j.jad.2013.11.013. Epub 2014
Jan 16.

Natural speech comprehension in bipolar disorders: an event-related brain
potential study among manic patients.

Cermolacce M(1), Faugère M(2), Micoulaud-Franchi JA(3), Belzeaux R(4), Maurel
M(5), Naudin J(6), Azorin JM(7), Vion-Dury J(3).

Author information:
(1)Département Universitaire de Psychiatrie, CHU Sainte Marguerite and
Aix-Marseille Université, Marseille, France; Unité de Neurophysiologie,
Psychophysiologie et Neurophénoménologie (UNPN), UF 4817, CHU Sainte Marguerite,
Marseille, France; Laboratoire de Neurosciences Cognitives, UMR CNRS 7291 &
Aix-Marseille Université, Fédération 3C, Marseille, France. Electronic address:
.
(2)Unité de Neurophysiologie, Psychophysiologie et Neurophénoménologie (UNPN), UF
4817, CHU Sainte Marguerite, Marseille, France; Laboratoire de Neurosciences
Cognitives, UMR CNRS 7291 & Aix-Marseille Université, Fédération 3C, Marseille,
France.
(3)Département Universitaire de Psychiatrie, CHU Sainte Marguerite and
Aix-Marseille Université, Marseille, France; Unité de Neurophysiologie,
Psychophysiologie et Neurophénoménologie (UNPN), UF 4817, CHU Sainte Marguerite,
Marseille, France; Laboratoire de Neurosciences Cognitives, UMR CNRS 7291 &
Aix-Marseille Université, Fédération 3C, Marseille, France; FondaMental,
Fondation de Recherche et de Soins en Santé Mentale, Créteil, France.
(4)Département Universitaire de Psychiatrie, CHU Sainte Marguerite and
Aix-Marseille Université, Marseille, France; CRN2M, UMR 7286 & Aix-Marseille
Université, Marseille, France; FondaMental, Fondation de Recherche et de Soins en
Santé Mentale, Créteil, France.
(5)Département Universitaire de Psychiatrie, CHU Sainte Marguerite and
Aix-Marseille Université, Marseille, France.
(6)Département Universitaire de Psychiatrie, CHU Sainte Marguerite and
Aix-Marseille Université, Marseille, France; Unité de Neurophysiologie,
Psychophysiologie et Neurophénoménologie (UNPN), UF 4817, CHU Sainte Marguerite,
Marseille, France; Laboratoire de Neurosciences Cognitives, UMR CNRS 7291 &
Aix-Marseille Université, Fédération 3C, Marseille, France.
(7)Département Universitaire de Psychiatrie, CHU Sainte Marguerite and
Aix-Marseille Université, Marseille, France; Institut de Neurosciences de la
Timone (INT), UMR CNRS 7289 & Aix-Marseille Université, Marseille, France;
FondaMental, Fondation de Recherche et de Soins en Santé Mentale, Créteil,
France.

BACKGROUND: Thought and language disturbances are crucial clinical features in
Bipolar Disorders (BD), and constitute a fundamental basis for social cognition.
In BD, clinical manifestations such as disorganization and formal thought
disorders may play a role in communication disturbances. However, only few
studies have explored language disturbances in BD at a neurophysiological level.
Two main Event-Related brain Potentials (ERPs) have been used in language
comprehension research: the N400 component, elicited by incongruous word with the
preceding semantic context, and the Late Positive Component (LPC), associated
with non-specifically semantic and more general cognitive processes. Previous
studies provided contradictory results regarding N400 in mood disorders, showing
either preserved N400 in depression or dysthymia, or altered N400 in BD during
semantic priming paradigm. The aim of our study was to explore N400 and LPC among
patients with BD in natural speech conditions.
METHODS: ERPs from 19 bipolar type I patients with manic or hypomanic
symptomatology and 19 healthy controls were recorded. Participants were asked to
listen to congruous and incongruous complete sentences and to judge the match
between the final word and the sentence context. Behavioral results and ERPs data
were analyzed.
RESULTS: At the behavioral level, patients with BD show worst performances than
healthy participants. At the electrophysiological level, our results show
preserved N400 component in BD. LPC elicited under natural speech conditions
shows preserved amplitude but delayed latency in difference waves.
LIMITATIONS: Small size of samples, absence of schizophrenic group and medication
status.
CONCLUSIONS: In contrast with the only previous N400 study in BD that uses
written semantic priming, our results show a preserved N400 component in
ecological and natural speech conditions among patients with BD. Possible
implications in terms of clinical specificity are discussed.

Copyright © 2013 Elsevier B.V. All rights reserved.

DOI: 10.1016/j.jad.2013.11.013
PMID: 24655781 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus