N-3 LCPUFA improves cognition: The young, the old and the sick

C. Joffre, A. Nadjar, M. Lebbadi, F. Calon, S. Laye
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2014-07-01; 91(1-2): 1-20
DOI: 10.1016/j.plefa.2014.05.001

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1. Prostaglandins Leukot Essent Fatty Acids. 2014 Jul-Aug;91(1-2):1-20. doi:
10.1016/j.plefa.2014.05.001. Epub 2014 May 14.

n-3 LCPUFA improves cognition: the young, the old and the sick.

Joffre C(1), Nadjar A(2), Lebbadi M(3), Calon F(4), Laye S(5).

Author information:
(1)Université Bordeaux, Nutrition and Integrative Neurobiology, UMR 1286, F-33000
Bordeaux, France; INRA, Nutrition and Integrative Neurobiology, UMR 1286, F-33000
Bordeaux, France. Electronic address: .
(2)Université Bordeaux, Nutrition and Integrative Neurobiology, UMR 1286, F-33000
Bordeaux, France; INRA, Nutrition and Integrative Neurobiology, UMR 1286, F-33000
Bordeaux, France. Electronic address: .
(3)Centre de Recherche du CHUL, Axe Neurosciences, T2-05, 2705, Boulevard
Laurier, Québec, QC, Canada G1V 4G2. Electronic address:
.
(4)Centre de Recherche du CHUL, Axe Neurosciences, T2-05, 2705, Boulevard
Laurier, Québec, QC, Canada G1V 4G2. Electronic address:
.
(5)Université Bordeaux, Nutrition and Integrative Neurobiology, UMR 1286, F-33000
Bordeaux, France; INRA, Nutrition and Integrative Neurobiology, UMR 1286, F-33000
Bordeaux, France. Electronic address: .

Due to the implication of docosahexaenoic acid (DHA) in neurogenesis,
synaptogenesis, neurite outgrowth and to its high incorporation into the brain,
this n-3 long chain polyunsaturated fatty acid (LCPUFA) is considered as crucial
in the development and maintenance of the learning memory performance throughout
life. In the present chapter we aimed at reviewing data investigating the
relation between DHA and cognition during the perinatal period, young adult- and
adulthood and neurodegenerative diseases such as Alzheimer disease (AD). In
Humans, dietary DHA supplementation from the perinatal period to adulthood does
not reveal a clear and consistent memory improvement whereas it is the case in
animal studies. The positive effects observed in animal models may have been
enhanced by using n-3 PUFA deficient animal models as controls. In animal models
of AD, a general consensus on the beneficial effects of n-3 LCPUFA in attenuating
cognitive impairment was established. These studies make DHA a potential suitable
micronutrient for the maintenance of cognitive performance at all periods of
life.

Copyright © 2014 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.plefa.2014.05.001
PMID: 24908517 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus