Multisite Intracerebral Microdialysis to Study the Mechanism of L-DOPA Induced Dopamine and Serotonin Release in the Parkinsonian Brain
ACS Chem. Neurosci.. 2013-04-15; 4(5): 680-692
DOI: 10.1021/CN400046E
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1. ACS Chem Neurosci. 2013 May 15;4(5):680-92. doi: 10.1021/cn400046e. Epub 2013
Apr 15.
Multisite intracerebral microdialysis to study the mechanism of L-DOPA induced
dopamine and serotonin release in the parkinsonian brain.
Navailles S(1), Lagière M, Contini A, De Deurwaerdère P.
Author information:
(1)Université de Bordeaux and ‡Centre National de la Recherche Scientifique,
Unité Mixte de Recherche 5293, Bordeaux Cedex, France.
L-DOPA is currently one of the best medications for Parkinson’s disease. It was
assumed for several years that its benefits and side effects were related to the
enhancement of dopamine release in the dopamine-depleted striatum. The use of
intracerebral microdialysis combined with a pharmacological approach has led to
the discovery that serotonergic neurons are responsible for dopamine release
induced by L-DOPA. The subsequent use of multisite microdialysis has further
revealed that L-DOPA-stimulated dopamine release is widespread and related to
the serotonergic innervation. The present Review emphasizes the functional
impact of extrastriatal release of dopamine induced by L-DOPA in both the
therapeutic and side effects of L-DOPA.