mTORC1 signaling in energy balance and metabolic disease.

1. Int J Obes (Lond). 2011 Jun;35(6):751-61. doi: 10.1038/ijo.2010.208. Epub 2010
Sep 28.

mTORC1 signaling in energy balance and metabolic disease.

Catania C(1), Binder E, Cota D.

Author information:
(1)INSERM U862, Avenir Group ‘Physiopathology of Energy Balance and Obesity’,
Bordeaux, France.

The mammalian target of rapamycin complex 1 (mTORC1) pathway regulates cellular
responses to fuel availability. Recent studies have demonstrated that within the
central nervous system, and in particular the hypothalamus, mTORC1 represents an
essential intracellular target for the actions of hormones and nutrients on food
intake and body weight regulation. By being at the crossroads of a
nutrient-hormonal signaling network, mTORC1 also controls important functions in
peripheral organs, such as muscle oxidative metabolism, white adipose tissue
differentiation and β-cell-dependent insulin secretion. Notably, dysregulation of
the mTORC1 pathway has been implicated in the development of obesity and
obesity-related conditions, such as type 2 diabetes. This manuscript will
therefore review recent progress made in understanding the role of the mTORC1
pathway in the regulation of energy balance and peripheral metabolism.
Furthermore, we will critically discuss the potential relevance of this
intracellular pathway as a therapeutic target for the treatment of metabolic
disease.

DOI: 10.1038/ijo.2010.208
PMID: 20877289 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus