MPTP induced hemiparkinsonism in monkeys: behavioral, mechanographic, electromyographic and immunohistochemical studies

A. Benazzouz, C. Gross, J. Dupont, B. Bioulac
Exp Brain Res. 1992-01-01; 90(1):
DOI: 10.1007/BF00229262

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1. Exp Brain Res. 1992;90(1):116-20. doi: 10.1007/BF00229262.

MPTP induced hemiparkinsonism in monkeys: behavioral, mechanographic,
electromyographic and immunohistochemical studies.

Benazzouz A(1), Gross C, Dupont J, Bioulac B.

Author information:
(1)Laboratoire de Neurophysiologie, CNRS URA 1200, Université de Bordeaux 2,
France.

A single infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP) into
the right internal carotid artery of Macaca mulatta monkeys resulted in akinesia
and rigidity of the contralateral limb. The immunohistochemical study revealed a
dramatic reduction in the number of TH-immunoreactive cells in the substantia
nigra of the infused side (70-81%). After unilateral MPTP-treatment movement
parameters and EMG activity were altered; the agonist muscle developed increased
EMG activity associated with a shift of antagonist muscle activity. These
results confirm that hemiparkinsonian monkeys are a valuable model of
parkinsonism which can be useful in studies of movement disorder physiology and
therapy of Parkinson’s disease.

DOI: 10.1007/BF00229262
PMID: 1355743 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus