Motor outcomes after neonatal arterial ischemic stroke related to early MRI data in a prospective study.
PEDIATRICS. 2010-09-20; 126(4): e912-e918
DOI: 10.1542/peds.2009-3611
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Husson B(1), Hertz-Pannier L, Renaud C, Allard D, Presles E, Landrieu P, Chabrier
S; AVCnn Group.
Collaborators: Testard H, Nzonzila J, Othmani K, Boutrolle M, Laboureau JP,
Lamoureux-Toth S, Masson P, Apéré H, Jouvencel P, Lazarro L, Rivera S,
Razafimanantsoa L, Thiriez G, Lachassine E, Mignot C, Audic-Gérard F, Brochard S,
Laparra V, Lefranc J, Peudenier S, Lecine T, Meier N, Gay S, Matta R, Gajdos V,
Lecomte B, Raqbi M, Tahraoui L, Barnérias C, Layouni I, Yousef N, d’Heilly N,
Granier M, Saunier P, Cneude F, Landrieu P, Legrez V, Tardieu M, Pierrat V,
Agudze E, Laroche C, Ville D, Garcia-Méric P, Roubertie A, Bru M, Nguyen The Tich
S, Perrier J, Routon MC, Delour L, Mallet S, Aujard Y, Farnoux C, Husson I,
Rajguru M, Saizou C, Blanc T, Charollais A, Marret S, Retbi JM, Bolot P, Chabrier
S, Mokhtari M, Villega F, Cheuret E, Glorieux I, Montjaux N, Lebon S, le Tallec
JY, Lakhdari Y, Saliba E, Mignot C, Moutard ML, Benbrik N, Soupre D, Cailho A,
Coudy C, Ringenbach C, Blanc N, Boivin MJ, Guillot F, Allard D, Hertz-Pannier L,
Husson B, Varlet MN, Tardy-Poncet B.
Author information:
(1)Department of Pediatric Radiology, Public Assistance Hospital of Paris, CHU
Bicêtre, 78 avenue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France.
Erratum in
Pediatrics. 2010 Nov;126(5):1053.
OBJECTIVE: We aimed to correlate early imaging data with motor outcomes in a
large, homogeneous, cohort of infants with neonatal (diagnosed before 29 days of
life) arterial ischemic stroke (AIS).
METHODS: From a prospective cohort of 100 children with neonatal AIS, we analyzed
the MRI studies performed within the 28 first days of life for 80 infants
evaluated at 2 years of age. The relationships between infarction location and
corticospinal tract (CST) involvement and motor outcomes were studied
RESULTS: Seventy-three infarctions involved the middle cerebral artery (MCA)
territory. Of those, 50 were superficial infarctions, 5 deep infarctions, and 18
mixed infarctions. The CST was involved in 24 cases. Nineteen patients with MCA
infarctions (26% [95% confidence interval: 16%-34%]) developed hemiplegia. Mixed
infarctions (P