MOTOR-ACTIVITY INCREASES TRYPTOPHAN, 5-HYDROXYINDOLEACETIC ACID, AND HOMOVANILLIC-ACID IN VENTRICULAR CEREBROSPINAL-FLUID OF THE CONSCIOUS RAT
J Neurochem. 1986-04-01; 46(4): 1313-1316
DOI: 10.1111/j.1471-4159.1986.tb00656.x
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Chaouloff F, Laude D, Guezennec Y, Elghozi JL.
An investigation was made into the effects of running (1 h at 20 m/min) on
central serotonergic and dopaminergic metabolism in trained rats. Methodology
involved continuous withdrawal of cerebrospinal fluid (CSF) from the third
ventricle of conscious rats and measurements of tryptophan (TRP),
5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA) levels during a
2 h post-exercise period. All three compounds were increased during the hour
following exercise and returned to their basal values within an hour later. CSF
flow rate was stable when metabolite levels were elevated. Brain determinations
indicated that CSF metabolite variations only qualitatively paralleled brain
changes. Indeed, post-exercise TRP, 5-HIAA, and HVA levels were increased to a
greater extent in brain when compared to CSF. It is suggested that increased
serotonergic and dopaminergic metabolism, caused by motor activity, may be
involved in the behavioral effects of exercise.