Mortality associated with time in and out of buprenorphine treatment in french office-based general practice: A 7-year cohort study
Ann Fam Med. 2017-07-01; 15(4): 355-358
DOI: 10.1370/afm.2098
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Dupouy J(1)(2), Palmaro A(2)(3), Fatséas M(4)(5), Auriacombe M(4)(5), Micallef J(6)(7), Oustric S(8)(2), Lapeyre-Mestre M(2)(3).
Author information:
(1)Département Universitaire de Médecine Générale, Université Toulouse III Paul Sabatier, Toulouse, France .
(2)Inserm UMR1027, Université Toulouse III Paul Sabatier; Faculté de Médecine, Toulouse, France.
(3)CEIP-Addictovigilance, CIC 1436, Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, Toulouse, France.
(4)Pôle Addictologie, CH Charles Perrens et CHU de Bordeaux, Bordeaux Cedex, France.
(5)SANPSY (Addiction Psychiatry Team), CNRS USR 3413, Université de Bordeaux, PAC Carreire, Bordeaux Cedex, France.
(6)CEIP-Addictovigilance Paca Corse, Service de Pharmacologie Clinique & Pharmacovigilance, Aix Marseille Université, Marseille, France.
(7)Institut de Neurosciences Timone, CNRS 7289, secteur PIICI, Marseille, France.
(8)Département Universitaire de Médecine Générale, Université Toulouse III Paul Sabatier, Toulouse, France.
In France, most cases of opioid use disorder are treated with buprenorphine by
general practitioners in private practice. Using reimbursement data of a
representative sample of the French population, Echantillon Généraliste des
Bénéficiaires, we investigated mortality during periods when patients were in and
out of treatment in a cohort of 713 new users of buprenorphine having a mean (SD)
follow-up of 4.5 (1.5) years. The mortality rate was 0.63 per 100 person-years
(95% CI, 0.40-0.85) overall. In a multivariate Cox regression model, compared
with being in treatment, being out of treatment was associated with a markedly
increased risk of death (hazard ratio = 29.04; 95% CI, 10.04-83.99).
Buprenorphine appears to be a strong protective factor against mortality.
© 2017 Annals of Family Medicine, Inc.
Conflict of interest statement: Conflicts of interest: authors report none.