Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of patients with Alzheimer’s disease at various cognitive stages
Sci Rep. 2018-01-17; 8(1):
DOI: 10.1038/s41598-018-19154-y
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1. Sci Rep. 2018 Jan 17;8(1):938. doi: 10.1038/s41598-018-19154-y.
Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of
patients with Alzheimer’s disease at various cognitive stages.
Poirel O(1), Mella S(1), Videau C(2), Ramet L(1), Davoli MA(3), Herzog E(1)(4),
Katsel P(5), Mechawar N(3), Haroutunian V(5), Epelbaum J(2)(6), Daumas S(7), El
Mestikawy S(8)(9).
Author information:
(1)Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Neurosciences Paris
Seine – Institut de Biologie Paris Seine (NPS – IBPS), 75005, Paris, France.
(2)Université Sorbonne Paris Cité, UMR-S894 Inserm Université Paris Descartes,
Centre de Psychiatrie et Neuroscience, 75014, Paris, France.
(3)Douglas Hospital Research Center, Department of Psychiatry, McGill University,
6875 boulevard Lasalle Verdun, Quebec, QC, Canada.
(4)Universités Bordeaux, CNRS, IINS, UMR 5297, F-33000, Bordeaux, France.
(5)Mount Sinai School of Medicine, Department of Psychiatry, NewYork, NY, USA.
(6)MECADEV UMR 7179 CNRS, Muséum National d’Histoire Naturelle, 91800, Brunoy,
France.
(7)Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Neurosciences Paris
Seine – Institut de Biologie Paris Seine (NPS – IBPS), 75005, Paris, France.
.
(8)Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Neurosciences Paris
Seine – Institut de Biologie Paris Seine (NPS – IBPS), 75005, Paris, France.
.
(9)Douglas Hospital Research Center, Department of Psychiatry, McGill University,
6875 boulevard Lasalle Verdun, Quebec, QC, Canada. .
Synaptic loss, plaques and neurofibrillary tangles are viewed as hallmarks of
Alzheimer’s disease (AD). This study investigated synaptic markers in neocortical
Brodmann area 9 (BA9) samples from 171 subjects with and without AD at different
levels of cognitive impairment. The expression levels of vesicular glutamate
transporters (VGLUT1&2), glutamate uptake site (EAAT2), post-synaptic density
protein of 95 kD (PSD95), vesicular GABA/glycine transporter (VIAAT),
somatostatin (som), synaptophysin and choline acetyl transferase (ChAT) were
evaluated. VGLUT2 and EAAT2 were unaffected by dementia. The VGLUT1, PSD95,
VIAAT, som, ChAT and synaptophysin expression levels significantly decreased as
dementia progressed. The maximal decrease varied between 12% (synaptophysin) and
42% (som). VGLUT1 was more strongly correlated with dementia than all of the
other markers (polyserial correlation = -0.41). Principal component analysis
using these markers was unable to differentiate the CDR groups from one another.
Therefore, the status of the major synaptic markers in BA9 does not seem to be
linked to the cognitive status of AD patients. The findings of this study suggest
that the loss of synaptic markers in BA9 is a late event that is only weakly
related to AD dementia.
DOI: 10.1038/s41598-018-19154-y
PMCID: PMC5772053
PMID: 29343737 [Indexed for MEDLINE]